The present success of organ transplantation is largely due to advances in immunosuppressive therapy. Progress has been made from a cytotoxic strategy associated with a high morbidity rate to a strategy that seeks to alter the activity of cells that regulate the immune response, in order to selectively dampen antidonor responses. This article presents a comprehensive review of the clinical matrix of immunosuppressive agents, which includes various combinations of pharmacologic agents tailored to minimize toxicity and to enhance efficacy.

Original languageEnglish (US)
Pages (from-to)1029-1054
Number of pages26
JournalSurgical Clinics of North America
Issue number5
StatePublished - 1994

ASJC Scopus subject areas

  • Surgery


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