TY - JOUR
T1 - Immunoregulatory Functions of Nuclear Receptors
T2 - Mechanisms and Therapeutic Implications
AU - Zhao, Linjie
AU - Gimple, Ryan C.
AU - Yang, Zhengnan
AU - Wei, Yuquan
AU - Gustafsson, Jan Åke
AU - Zhou, Shengtao
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/10/2
Y1 - 2019/10/2
N2 - Members of the nuclear receptor superfamily serve as master regulators in signaling by either positively or negatively regulating gene expression. Accumulating evidence has suggested that nuclear receptors are actively involved in immune responses, with specific roles in different immune cell compartments that contribute to both normal function and to disease development. The druggable properties of nuclear receptors have made them ideal modulatory therapeutic targets. Here, we revisit nuclear receptor biology, summarize recent advances in our understanding of the immunological functions of nuclear receptors, describe cell-type-specific roles and specific nuclear receptors in disease pathogenesis, and explore their potential as novel therapeutic targets. These nuclear receptor-dependent alterations in the immune system are amenable to pharmacological manipulation and suggest novel therapeutic strategies.
AB - Members of the nuclear receptor superfamily serve as master regulators in signaling by either positively or negatively regulating gene expression. Accumulating evidence has suggested that nuclear receptors are actively involved in immune responses, with specific roles in different immune cell compartments that contribute to both normal function and to disease development. The druggable properties of nuclear receptors have made them ideal modulatory therapeutic targets. Here, we revisit nuclear receptor biology, summarize recent advances in our understanding of the immunological functions of nuclear receptors, describe cell-type-specific roles and specific nuclear receptors in disease pathogenesis, and explore their potential as novel therapeutic targets. These nuclear receptor-dependent alterations in the immune system are amenable to pharmacological manipulation and suggest novel therapeutic strategies.
UR - http://www.scopus.com/inward/record.url?scp=85075439804&partnerID=8YFLogxK
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U2 - 10.1016/j.tem.2019.10.002
DO - 10.1016/j.tem.2019.10.002
M3 - Review article
C2 - 31706690
AN - SCOPUS:85075439804
SN - 1043-2760
VL - 31
SP - 93
EP - 106
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 2
ER -