Immunoreactive somatostatin in human pancreatic secretion

Atilla Ertan, Tomohiko Taminato, Kemal Akdamar, Jerome Ryan, Naurang M. Agrawal, Andrew V. Schally, Akira Arimura

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Somatostatin in human pancreatic juice collected during endoscopic retrograde cholangiopancreatography following secretin injection was determined by RIA. The mean immunoreactive somatostatin (IRS) levels in the pancreatic juice of 13 non-diabetics was 78 ± 11 (SE) pg/ml. The IRS levels in 4 non-insulin-dependent diabetics ranged from 843 to 2286 pg/ml with a mean of 1559 ± 392 (SE) pg/ml. This was significantly greater than non-diabetic values. The IRS in the pancreatic juice was immunologically indistinguishable from somatostatin 14 but consisted of 2 major components, one corresponding to somatostatin 14 and the other being of a molecular size of approximately 3000 daltons.

Original languageEnglish (US)
Pages (from-to)589-591
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Issue number3
StatePublished - Mar 1981

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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