Immunoperoxidase localization of prostatic acid phosphatase in prostatic carcinoma with sarcomatoid changes

Nelson G. Ordoñez, Alberto Ayala, Andrew C. Von Eschenbach, Bruce Mackay, Genarina Hanssen

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Immunoperoxidase staining of tissue for prostatic acid phosphatase has been useful in confirming the prostatic origin of metastatic deposits. This technique was used on the prostate tumors of 2 patients to differentiate between a true carcinosarcoma and a pure epithelial carcinoma with sarcomatoid changes. Positive staining for prostatic acid phosphatase in both the sarcomatoid element, as well as the area of well-differentiated carcinoma, confirmed the common epithelial cell origin of these components. Electron microscopy further confirmed these findings by demonstrating desmosomes in the sarcomatoid areas. Although each type of tumor is rare, differentiation between true carcinosarcomas and true carcinomas with sarcomatoid changes is important to elucidate further their different clinical behaviors and responses to therapy.

Original languageEnglish (US)
Pages (from-to)210-214
Number of pages5
JournalUrology
Volume19
Issue number2
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Urology

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