Immunology: Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function

Gyangyong Peng, Zhong Guo, Yukiko Kiniwa, Kui Shin Voo, Weiyi Peng, Tihui Fu, Daniel Y. Wang, Yanchun Li, Helen Y. Wang, Rong Fu Wang

Research output: Contribution to journalArticlepeer-review

629 Scopus citations

Abstract

CD4+ regulatory T (Treg) cells have a profound ability to suppress host immune responses, yet little is understood about how these cells are regulated. We describe a mechanism linking Toll-like receptor (TLR) 8 signaling to the control of Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse Treg cell function. This effect was independent of dendritic cells but required functional TLR8-MyD88-IRAK4 signaling in Treg cells. Adoptive transfer of TLR8 ligand-stimulated Treg cells into tumor-bearing mice enhanced antitumor immunity. These results suggest that TLR8 signaling could play a critical role in controlling immune responses to cancer and other diseases.

Original languageEnglish (US)
Pages (from-to)1380-1384
Number of pages5
JournalScience
Volume309
Issue number5739
DOIs
StatePublished - Aug 26 2005

ASJC Scopus subject areas

  • General

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