Immunology: Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function

Gyangyong Peng; Zhong Guo; Yukiko Kiniwa; Kui Shin Voo; Weiyi Peng; Tihui Fu; Daniel Y. Wang; Yanchun Li; Helen Y. Wang; Rong Fu Wang

doi:10.1126/science.1113401

Immunology: Toll-like receptor 8-mediated reversal of CD4⁺ regulatory T cell function

Gyangyong Peng, Zhong Guo, Yukiko Kiniwa, Kui Shin Voo, Weiyi Peng, Tihui Fu, Daniel Y. Wang, Yanchun Li, Helen Y. Wang, Rong Fu Wang

Research output: Contribution to journal › Article › peer-review

696 Scopus citations

Abstract

CD4⁺ regulatory T (Treg) cells have a profound ability to suppress host immune responses, yet little is understood about how these cells are regulated. We describe a mechanism linking Toll-like receptor (TLR) 8 signaling to the control of Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse Treg cell function. This effect was independent of dendritic cells but required functional TLR8-MyD88-IRAK4 signaling in Treg cells. Adoptive transfer of TLR8 ligand-stimulated Treg cells into tumor-bearing mice enhanced antitumor immunity. These results suggest that TLR8 signaling could play a critical role in controlling immune responses to cancer and other diseases.

Original language	English (US)
Pages (from-to)	1380-1384
Number of pages	5
Journal	Science
Volume	309
Issue number	5739
DOIs	https://doi.org/10.1126/science.1113401
State	Published - Aug 26 2005

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title = "Immunology: Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function",

abstract = "CD4+ regulatory T (Treg) cells have a profound ability to suppress host immune responses, yet little is understood about how these cells are regulated. We describe a mechanism linking Toll-like receptor (TLR) 8 signaling to the control of Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse Treg cell function. This effect was independent of dendritic cells but required functional TLR8-MyD88-IRAK4 signaling in Treg cells. Adoptive transfer of TLR8 ligand-stimulated Treg cells into tumor-bearing mice enhanced antitumor immunity. These results suggest that TLR8 signaling could play a critical role in controlling immune responses to cancer and other diseases.",

author = "Gyangyong Peng and Zhong Guo and Yukiko Kiniwa and Voo, {Kui Shin} and Weiyi Peng and Tihui Fu and Wang, {Daniel Y.} and Yanchun Li and Wang, {Helen Y.} and Wang, {Rong Fu}",

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doi = "10.1126/science.1113401",

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T2 - Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function

AU - Peng, Gyangyong

AU - Guo, Zhong

AU - Kiniwa, Yukiko

AU - Voo, Kui Shin

AU - Peng, Weiyi

AU - Fu, Tihui

AU - Wang, Daniel Y.

AU - Li, Yanchun

AU - Wang, Helen Y.

AU - Wang, Rong Fu

PY - 2005/8/26

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AB - CD4+ regulatory T (Treg) cells have a profound ability to suppress host immune responses, yet little is understood about how these cells are regulated. We describe a mechanism linking Toll-like receptor (TLR) 8 signaling to the control of Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse Treg cell function. This effect was independent of dendritic cells but required functional TLR8-MyD88-IRAK4 signaling in Treg cells. Adoptive transfer of TLR8 ligand-stimulated Treg cells into tumor-bearing mice enhanced antitumor immunity. These results suggest that TLR8 signaling could play a critical role in controlling immune responses to cancer and other diseases.

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Immunology: Toll-like receptor 8-mediated reversal of CD4⁺ regulatory T cell function

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