Immunology of HIV infection

Dorothy E. Lewis, Janis V. Giorgi

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The goal of finding an effective vaccine against the human immunodeficiency virus (HIV) is hampered by our uncertainty of the mechanism(s) responsible for the pathogenesis as well as the lack of knowledge of protective mechanisms. The effects of HIV on the immune system are myriad and thus the truly significant manifestations of the pathology are difficult to dissociate from those more peripheral. In this article we will initially characterize the natural history of HIV infection which shows a chronic and perhaps inexorable course. The second part will deal with the immune response mounted against this assault and the final section is a discussion of the possible unfavorable consequences of the immune response that humans muster against this agent.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalInternational Reviews of Immunology
Issue number1
StatePublished - Jan 1 1990


  • Cellular response to HIV
  • HIV infection
  • Humoral response to HIV
  • Immune response to HIV
  • Natural history of HIV
  • Pathogenesis of HIV

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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