Immunologic Mechanisms of Multiple Sclerosis

Research output: Contribution to journalReview article

Elliot M. Frohman, Todd N. Eagar, Nancy Monson, Olaf Stuve, Nitin Karandikar

Multiple sclerosis is widely recognized as the most commonly identified cause of progressive neurologic disability in young adults throughout the developed world. The disorder is clinically suspected when patients experience either acute attacks of neurologic compromise or instead are afflicted by a steadily progressive deterioration in functional capabilities. The pathophysiology of acute exacerbations is thought to be related to the development of inflammation and its consequences, within strategic and often discrete central nervous system tract systems. Although a myriad of hypotheses have been formulated to explain the underpinnings of the mechanisms that contribute to both the predilection and triggering of the multiphasic inflammatory events that personify multiple sclerosis, much remains to be done to understand fully the specific set and sequence of events that produce the disease and its cardinal features.

Original languageEnglish (US)
Pages (from-to)577-588
Number of pages12
JournalNeuroimaging Clinics of North America
Volume18
Issue number4
DOIs
StatePublished - Nov 1 2008

PMID: 19068403

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Immunologic Mechanisms of Multiple Sclerosis. / Frohman, Elliot M.; Eagar, Todd N.; Monson, Nancy; Stuve, Olaf; Karandikar, Nitin.

In: Neuroimaging Clinics of North America, Vol. 18, No. 4, 01.11.2008, p. 577-588.

Research output: Contribution to journalReview article

Harvard

Frohman, EM, Eagar, TN, Monson, N, Stuve, O & Karandikar, N 2008, 'Immunologic Mechanisms of Multiple Sclerosis' Neuroimaging Clinics of North America, vol. 18, no. 4, pp. 577-588. https://doi.org/10.1016/j.nic.2008.06.009

APA

Frohman, E. M., Eagar, T. N., Monson, N., Stuve, O., & Karandikar, N. (2008). Immunologic Mechanisms of Multiple Sclerosis. Neuroimaging Clinics of North America, 18(4), 577-588. https://doi.org/10.1016/j.nic.2008.06.009

Vancouver

Frohman EM, Eagar TN, Monson N, Stuve O, Karandikar N. Immunologic Mechanisms of Multiple Sclerosis. Neuroimaging Clinics of North America. 2008 Nov 1;18(4):577-588. https://doi.org/10.1016/j.nic.2008.06.009

Author

Frohman, Elliot M. ; Eagar, Todd N. ; Monson, Nancy ; Stuve, Olaf ; Karandikar, Nitin. / Immunologic Mechanisms of Multiple Sclerosis. In: Neuroimaging Clinics of North America. 2008 ; Vol. 18, No. 4. pp. 577-588.

BibTeX

@article{806550d701db49af818207301454bac8,
title = "Immunologic Mechanisms of Multiple Sclerosis",
abstract = "Multiple sclerosis is widely recognized as the most commonly identified cause of progressive neurologic disability in young adults throughout the developed world. The disorder is clinically suspected when patients experience either acute attacks of neurologic compromise or instead are afflicted by a steadily progressive deterioration in functional capabilities. The pathophysiology of acute exacerbations is thought to be related to the development of inflammation and its consequences, within strategic and often discrete central nervous system tract systems. Although a myriad of hypotheses have been formulated to explain the underpinnings of the mechanisms that contribute to both the predilection and triggering of the multiphasic inflammatory events that personify multiple sclerosis, much remains to be done to understand fully the specific set and sequence of events that produce the disease and its cardinal features.",
keywords = "Macular volume, Multiple sclerosis, Optical coherence tomography, Pupillometry, Retinal nerve fiber layer",
author = "Frohman, {Elliot M.} and Eagar, {Todd N.} and Nancy Monson and Olaf Stuve and Nitin Karandikar",
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doi = "10.1016/j.nic.2008.06.009",
language = "English (US)",
volume = "18",
pages = "577--588",
journal = "Neuroimaging Clinics of North America",
issn = "1052-5149",
publisher = "W.B. Saunders Ltd",
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}

RIS

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T1 - Immunologic Mechanisms of Multiple Sclerosis

AU - Frohman, Elliot M.

AU - Eagar, Todd N.

AU - Monson, Nancy

AU - Stuve, Olaf

AU - Karandikar, Nitin

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Multiple sclerosis is widely recognized as the most commonly identified cause of progressive neurologic disability in young adults throughout the developed world. The disorder is clinically suspected when patients experience either acute attacks of neurologic compromise or instead are afflicted by a steadily progressive deterioration in functional capabilities. The pathophysiology of acute exacerbations is thought to be related to the development of inflammation and its consequences, within strategic and often discrete central nervous system tract systems. Although a myriad of hypotheses have been formulated to explain the underpinnings of the mechanisms that contribute to both the predilection and triggering of the multiphasic inflammatory events that personify multiple sclerosis, much remains to be done to understand fully the specific set and sequence of events that produce the disease and its cardinal features.

AB - Multiple sclerosis is widely recognized as the most commonly identified cause of progressive neurologic disability in young adults throughout the developed world. The disorder is clinically suspected when patients experience either acute attacks of neurologic compromise or instead are afflicted by a steadily progressive deterioration in functional capabilities. The pathophysiology of acute exacerbations is thought to be related to the development of inflammation and its consequences, within strategic and often discrete central nervous system tract systems. Although a myriad of hypotheses have been formulated to explain the underpinnings of the mechanisms that contribute to both the predilection and triggering of the multiphasic inflammatory events that personify multiple sclerosis, much remains to be done to understand fully the specific set and sequence of events that produce the disease and its cardinal features.

KW - Macular volume

KW - Multiple sclerosis

KW - Optical coherence tomography

KW - Pupillometry

KW - Retinal nerve fiber layer

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U2 - 10.1016/j.nic.2008.06.009

DO - 10.1016/j.nic.2008.06.009

M3 - Review article

VL - 18

SP - 577

EP - 588

JO - Neuroimaging Clinics of North America

T2 - Neuroimaging Clinics of North America

JF - Neuroimaging Clinics of North America

SN - 1052-5149

IS - 4

ER -

ID: 16793634