@article{ed5ff6a0132e4f3a9dcb2c64ba16c582,
title = "Immunolocalization of apolipoproteins in aortic atherosclerosis in American youths and young adults: Findings from the PDAY study",
abstract = "The immunohistochemical distribution of apolipoproteins in the abdominal aortas of 142 men, 15-34 years of age, collected in a cooperative multicenter study group (Pathobiological Determinants of Atherosclerosis in Youth) was examined in relationship to serum VLDL + LDL + HDL cholesterol levels. ApoB deposits were limited to the intima of specimens with intimal fibro cellular thickening or atherosclerotic lesions. Apo A-I, E and J were observed in both the intima and media of the aortas with intimal lesions. The pattern of apoJ distribution was similar to that of apoA-I and E. The distribution patterns of these apolipoproteins in these young adults were very similar to those in adults and old men seen in an earlier study. The extent of apolipoprotein distribution in the intima and media increased with age and the stage of atherosclerosis development, but was not correlated significantly with serum VLDL + LDL or HDL cholesterol levels. The infiltration of lipoprotein particles into the aortic wall seems to be more strongly associated with the progression of intimal lesions rather than with serum cholesterol levels.",
keywords = "Apolipoproteins, Atherosclerosis, Immunohistochemistry, Pathobiological Determinants of Atherosclerosis in Youth (PDAY)",
author = "Yukio Ishikawa and Toshiharu Ishii and Yoshikiyo Akasaka and Takao Masuda and Strong, {Jack P.} and Zieske, {Arthur W.} and Hidehiro Takei and Malcom, {Gray T.} and Matsuo Taniyama and Choi-Miura, {Nam Ho} and Motowo Tomita",
note = "Funding Information: We are grateful to Senroku Saito for their excellent technical assistance throughout the study. We thank the PDAY group for providing the specimens and data. This study was supported in part by the Japanese-United States Cooperative Agreement in the Cardiovascular Area by the Japanese National Cardiovascular Disease Center in Osaka and the United States Heart, Lung and Blood Institute of the National Institutes of Health in Bethesda, MD, Grant HL-08974, and a grant from the Japanese Ministry of Education (11670197). The PDAY research group is as follows: Program Director, Jack P. Strong, MD, 1996 to date, and Robert W. Wissler, PhD, MD, 1985–1996. Steering Committee, J. Fredrick Comhill, DPhil; Henry C. McGill, Jr, MD; C. Alex McMahan, PhD; Gray T. Malcom, PhD; Margaret C. Qalmann, DrPH; Robert W. Wissler, PhD, MD; and Jack P. Strong, MD. Participating centers, principal and coinvestigators, and supporting grants from the National Heart, Lung and Blood Institute, University of Alabama, Birmingham: Department of Medicine, Steffen Gay, MD (grant HL-33733), and Department of Biochemistry, Edwards J. Miller, PhD (ML-33728); Albany (NY) Medical College, Assad Daoud, MD, and Adriene S. Frank, PhD (ML-33765); Baylor College of Medicine, Houston, Tex: Louis C. Smith, PhD (HL-33750); University of Chicago (III), Robert W. Wissler, PhD, MD; Dragoslava Vesselinovitch, DVM, MS; Akio Komatsu, MD, PhD; Yoshiaki Kusumi, MD; Toshinori Omuma, MD; Alyna Chien, MA; Alexis Demopoulos, MD; Gertrud Friedman, BA; R. Timothy Bridenstine, MS; Robert J. Stein, MD; Robert H. Kirschner, MD; Manuela Bekermeier, ASCP; Blanche Berger, ASCP; and Laura Hiltscher, ASCP (HL-33740; HL-45715); University of Illinois, Chicago: Abel L. Robertson, Jr, MD, PhD; Robert J. Stein, MD; Edmund R. Donoghue, MD; Robert J. Buschmann, MD; and Yoshihisa Katsura, MD (ML-33758); Louisiana State University Medical Center, New Orleans: Jack P. Strong, MD; Gray T. Malcom, PhD; William P. Newman III, MD; Margaret C. Oalmann, DrPH; Richard E. Tracy, MD, PhD; Cynthia S. Zsembik, BS; DeAnne G. Gibbs, BS; and Dana A. Troxclair, MS (HL-33746 and HL-45720); University of Maryland, Baltimore: Wolfgang Merguer, MD, PhD; Catherine Cole, PhD; and J. Smialek, MD (HL-33752 and HL-45693); Medical College of Georgia, Augusta; A. Bleakley Chandler, MD; Raghunatha N. Rao, MD; D. Greer Falls, MD, Ross G. Gerrity, PhD; Benjamin O. Spurlock, BA; Kalish B. Sharma, MD; and Joel S. Sexton, MD (HL-33772); University of Nebraska Medical Center, Omaha: Bruce M. McManus, MD, PhD, and Jerry W. Jones, MD (HL-33778); Ohio State University, Columbus: J. Fredrick Coruhill, Dphil; William R. Adrion, MD; Patrick M. Fardel, MD; Brian Gara, MS; Edward Herderick, BS; and Larry R. Tate, MD (HL-33760 and HL-45694); Southwest Foundation for Biomedical Research, San Antonio, Tex; James E. Hixson, PhD (HL-39913); the University of Texas Health Science Center at San Antonio: C. Alex McMahan, PhD; Henry C. McGill, Jr, MD; Yolan Marinez, MA; and Thomas J. Prihoda, PhD (HL-33749 and HL-45719); Vanderbilt University, Nashville, Tenn: Renu Virmani, MD; James B. Atkinson, MD, PhD; and Charles W. Harlan, MD (HL-33770 and HL-45718); and West Virginia University Health Science Center, Morgantown; Singanallur N. Jagannathan, PhD, and James Frost, MD (HL-33748).",
year = "2001",
doi = "10.1016/S0021-9150(01)00416-6",
language = "English (US)",
volume = "158",
pages = "215--225",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "1",
}