Immunohistochemical characterization of pulmonary blastoma

K. Berean; Luan Truong; A. W. Dudley; Philip T. Cagle

doi:10.1093/ajcp/89.6.773

Immunohistochemical characterization of pulmonary blastoma

K. Berean, Luan Truong, A. W. Dudley, Philip T. Cagle

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Abstract

The immunohistochemical staining patterns of three pulmonary blastomas (PBs) were studied for markers of mesenchymal (vimentin, muscle-specific actin) and epithelial (cytokeratin, epithelial membrane antigen) differentiation to clarify their phenotypic nature and, possibly, their histogenesis. Epithelial markers were confined to the tubular component of the tumors, and the mesenchymal markers were confined to the stromal component, demonstrating that PBs are true mixed tumors. These findings are consistent with origin from a primitive pluripotential stem cell but do not rule out derivation from a single germ layer with subsequent metaplastic transformation.

Original language	English (US)
Pages (from-to)	773-777
Number of pages	5
Journal	American Journal of Clinical Pathology
Volume	89
Issue number	6
DOIs	https://doi.org/10.1093/ajcp/89.6.773
State	Published - Jan 1 1988

ASJC Scopus subject areas

Pathology and Forensic Medicine

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AU - Cagle, Philip T.

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N2 - The immunohistochemical staining patterns of three pulmonary blastomas (PBs) were studied for markers of mesenchymal (vimentin, muscle-specific actin) and epithelial (cytokeratin, epithelial membrane antigen) differentiation to clarify their phenotypic nature and, possibly, their histogenesis. Epithelial markers were confined to the tubular component of the tumors, and the mesenchymal markers were confined to the stromal component, demonstrating that PBs are true mixed tumors. These findings are consistent with origin from a primitive pluripotential stem cell but do not rule out derivation from a single germ layer with subsequent metaplastic transformation.

AB - The immunohistochemical staining patterns of three pulmonary blastomas (PBs) were studied for markers of mesenchymal (vimentin, muscle-specific actin) and epithelial (cytokeratin, epithelial membrane antigen) differentiation to clarify their phenotypic nature and, possibly, their histogenesis. Epithelial markers were confined to the tubular component of the tumors, and the mesenchymal markers were confined to the stromal component, demonstrating that PBs are true mixed tumors. These findings are consistent with origin from a primitive pluripotential stem cell but do not rule out derivation from a single germ layer with subsequent metaplastic transformation.

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Immunohistochemical characterization of pulmonary blastoma

Abstract

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