TY - JOUR
T1 - Immunohistochemical characterization of pulmonary blastoma
AU - Berean, K.
AU - Truong, Luan
AU - Dudley, A. W.
AU - Cagle, Philip T.
PY - 1988/1/1
Y1 - 1988/1/1
N2 - The immunohistochemical staining patterns of three pulmonary blastomas (PBs) were studied for markers of mesenchymal (vimentin, muscle-specific actin) and epithelial (cytokeratin, epithelial membrane antigen) differentiation to clarify their phenotypic nature and, possibly, their histogenesis. Epithelial markers were confined to the tubular component of the tumors, and the mesenchymal markers were confined to the stromal component, demonstrating that PBs are true mixed tumors. These findings are consistent with origin from a primitive pluripotential stem cell but do not rule out derivation from a single germ layer with subsequent metaplastic transformation.
AB - The immunohistochemical staining patterns of three pulmonary blastomas (PBs) were studied for markers of mesenchymal (vimentin, muscle-specific actin) and epithelial (cytokeratin, epithelial membrane antigen) differentiation to clarify their phenotypic nature and, possibly, their histogenesis. Epithelial markers were confined to the tubular component of the tumors, and the mesenchymal markers were confined to the stromal component, demonstrating that PBs are true mixed tumors. These findings are consistent with origin from a primitive pluripotential stem cell but do not rule out derivation from a single germ layer with subsequent metaplastic transformation.
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U2 - 10.1093/ajcp/89.6.773
DO - 10.1093/ajcp/89.6.773
M3 - Article
C2 - 3369370
AN - SCOPUS:0023918361
SN - 0002-9173
VL - 89
SP - 773
EP - 777
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
IS - 6
ER -