Immunoglobulin therapy for plasma cell-rich rejection in the renal allograft

Horacio E. Adrogue, Liliana Soltero, Geoffrey A. Land, Venkataraman Ramanathan, Luan Truong, Wadi N. Suki

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Plasma cell-rich acute rejection (PCAR) is associated with poor allograft outcome in renal transplantation. Previous studies report a graft half-life of six months after a single PCAR episode. However, the management of this condition is unclear. Intravenous immunoglobulin (IVIG) therapy, by virtue of its immunomodulating properties, and its influence on B-cell maturation into plasma cells, may be a good candidate for reversing this type of rejection. We report four episodes of PCAR in two patients who responded well to IVIG with improvement in renal function.

Original languageEnglish (US)
Pages (from-to)567-569
Number of pages3
JournalTransplantation
Volume82
Issue number4
DOIs
StatePublished - Aug 1 2006

Keywords

  • Antibodies
  • Graft loss
  • Humoral rejection
  • Intravenous immunoglobulin
  • Plasmapheresis

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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