Immunogenicity of the Haemophilus influenzae type b capsular polysaccharide conjugate vaccine in children after systemic Haemophilus influenzae type b infections

Sheldon Kaplan, John M. Zahradnik, Edward Mason, Cynthia M. Dukes

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We immunized 24 patients (mean age 15.2±9.3 months) with polyribosylribitol phosphate-diphtheria toxoid conjugate vaccine (PRP-D) 2 months after a systemic Haemophilus influenzae type b infection. Children <24 months of age were immunized twice. Serum was obtained for antibody to PRP before and 1 or 2 months after immunization. Three of five children >24 months of age and three of six children 18 to 24 months of age developed >1 μg/ml of antibody after immunization, and geometric mean postimmunization levels were significantly greater than preimmunization levels for both groups. However, two children who failed to respond to conventional PRP vaccine did not respond as expected to one dose of PRP-D. For children 7 to 17 months of age, the geometric mean PRP antibody levels increased as follows: preimmunization, 0.05 μg/ml; after the first dose, 0.28 μg/ml (p=0.003); and after the second dose, 3.39 μg/ml (p=0.001). Of 13 children, 10 developed antibody values >1.0 μg/ml. PRP conjugate vaccines are immunogenic in young children who have not developed protective PRP antibody levels after a systemic H. Influenzae type b infection.

Original languageEnglish (US)
Pages (from-to)272-277
Number of pages6
JournalThe Journal of Pediatrics
Volume113
Issue number2
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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