Immunogenicity of Haemophilus influenzae type b polysaccharide-tetanus protein conjugate vaccine in children with sickle hemoglobinopathy or malignancies, and after systemic Haemophilus influenzae type b infection

Sheldon Kaplan, Teresa Duckett, Donald H. Mahoney, Laura L. Kennedy, Cindy M. Dukes, Don M. Schaffer, Edward Mason

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

To determine the immunogenicity of Haemophilus influenzae type b polysaccharide-tetanus protein conjugate vaccine in specific populations at risk, we administered vaccine to children with sickle cell anemia (n=19; mean age, 18.3 months, malignancies (n=18; mean age, 43.1 months), or a recent history of systemic H. influenzae type b infection (n=17; mean age, 11.9 months). After one dose of polyribosylribitol phosphate-tetanus toxoid conjugate vaccine the geometric mean titers for polyribosylribitol phosphate antibody were 4.8 μg/ml (14/19 >1 μg/ml), 1.4 μg/ml (9/18 >1 μg/ml), and 5.6 μg/ml (15/17 >1 μg/ml) in these three groups, respectively. Children with sickle cell anemia or a recent history of systemic H. influenzae type b infection had polyribosylribitol phosphate antibody levels comparable to those of normal children of similar age after one or two doses of polyribosylribitol phosphate-tetanus toxoid conjugate vaccine. We conclude that this vaccine is immunogenic in children with underlying conditions associated with an increased risk of H. influenzae type b infection.

Original languageEnglish (US)
Pages (from-to)367-370
Number of pages4
JournalThe Journal of Pediatrics
Volume120
Issue number3
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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