Immunogenicity and safety of Haemophilus influenzae type b-tetanus protein conjugate vaccine alone or mixed with diphtheria-tetanus-pertussis vaccine in infants

Sheldon L. Kaplan; Brian A. Lauer; Mark A. Ward; Bernhard L. Wiedermann; Kenneth M. Boyer; Cindy M. Dukes; Don M. Schaffer; John Paisley; Robert Mendelson; Frank Pedreira; Bernard Fritzell

doi:10.1016/S0022-3476(94)70328-0

Immunogenicity and safety of Haemophilus influenzae type b-tetanus protein conjugate vaccine alone or mixed with diphtheria-tetanus-pertussis vaccine in infants

Sheldon L. Kaplan, Brian A. Lauer, Mark A. Ward, Bernhard L. Wiedermann, Kenneth M. Boyer, Cindy M. Dukes, Don M. Schaffer, John Paisley, Robert Mendelson, Frank Pedreira, Bernard Fritzell

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Haemophilus capsular polysaccharide-tetanus toxoid conjugate (PRP-T) and diphtheria-tetanus-pertussis (DTP) vaccines were administered in a single syringe (group 1) or separate syringes (group 2) to 284 infants at 2, 4, and 6 months of age. Group 1 infants had a slightly greater incidence of local reactions. Systemic reactions were similar. The geometric mean titers of polyribosylribitol phosphate (PRP) serum antibody concentrations after the third dose of PRP-T vaccine were 4.8 and 4.3 μg/ml for groups 1 and 2, respectively. Antibody responses to DTP antigens were also similar. The immunogenicity and safety of the PRP-T and DTP vaccines are equivalent when the vaccines are administered in separate syringes or the same syringe to infants. (J PEDIATR 1994;124:323-7).

Original language	English (US)
Pages (from-to)	323-327
Number of pages	5
Journal	The Journal of Pediatrics
Volume	124
Issue number	2
DOIs	https://doi.org/10.1016/S0022-3476(94)70328-0
State	Published - Feb 1994

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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Kaplan, S. L., Lauer, B. A., Ward, M. A., Wiedermann, B. L., Boyer, K. M., Dukes, C. M., Schaffer, D. M., Paisley, J., Mendelson, R., Pedreira, F., & Fritzell, B. (1994). Immunogenicity and safety of Haemophilus influenzae type b-tetanus protein conjugate vaccine alone or mixed with diphtheria-tetanus-pertussis vaccine in infants. The Journal of Pediatrics, 124(2), 323-327. https://doi.org/10.1016/S0022-3476(94)70328-0

Kaplan, SL, Lauer, BA, Ward, MA, Wiedermann, BL, Boyer, KM, Dukes, CM, Schaffer, DM, Paisley, J, Mendelson, R, Pedreira, F & Fritzell, B 1994, 'Immunogenicity and safety of Haemophilus influenzae type b-tetanus protein conjugate vaccine alone or mixed with diphtheria-tetanus-pertussis vaccine in infants', The Journal of Pediatrics, vol. 124, no. 2, pp. 323-327. https://doi.org/10.1016/S0022-3476(94)70328-0

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title = "Immunogenicity and safety of Haemophilus influenzae type b-tetanus protein conjugate vaccine alone or mixed with diphtheria-tetanus-pertussis vaccine in infants",

abstract = "Haemophilus capsular polysaccharide-tetanus toxoid conjugate (PRP-T) and diphtheria-tetanus-pertussis (DTP) vaccines were administered in a single syringe (group 1) or separate syringes (group 2) to 284 infants at 2, 4, and 6 months of age. Group 1 infants had a slightly greater incidence of local reactions. Systemic reactions were similar. The geometric mean titers of polyribosylribitol phosphate (PRP) serum antibody concentrations after the third dose of PRP-T vaccine were 4.8 and 4.3 μg/ml for groups 1 and 2, respectively. Antibody responses to DTP antigens were also similar. The immunogenicity and safety of the PRP-T and DTP vaccines are equivalent when the vaccines are administered in separate syringes or the same syringe to infants. (J PEDIATR 1994;124:323-7).",

author = "Kaplan, \{Sheldon L.\} and Lauer, \{Brian A.\} and Ward, \{Mark A.\} and Wiedermann, \{Bernhard L.\} and Boyer, \{Kenneth M.\} and Dukes, \{Cindy M.\} and Schaffer, \{Don M.\} and John Paisley and Robert Mendelson and Frank Pedreira and Bernard Fritzell",

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doi = "10.1016/S0022-3476(94)70328-0",

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AU - Kaplan, Sheldon L.

AU - Lauer, Brian A.

AU - Ward, Mark A.

AU - Wiedermann, Bernhard L.

AU - Boyer, Kenneth M.

AU - Dukes, Cindy M.

AU - Schaffer, Don M.

AU - Paisley, John

AU - Mendelson, Robert

AU - Pedreira, Frank

AU - Fritzell, Bernard

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AB - Haemophilus capsular polysaccharide-tetanus toxoid conjugate (PRP-T) and diphtheria-tetanus-pertussis (DTP) vaccines were administered in a single syringe (group 1) or separate syringes (group 2) to 284 infants at 2, 4, and 6 months of age. Group 1 infants had a slightly greater incidence of local reactions. Systemic reactions were similar. The geometric mean titers of polyribosylribitol phosphate (PRP) serum antibody concentrations after the third dose of PRP-T vaccine were 4.8 and 4.3 μg/ml for groups 1 and 2, respectively. Antibody responses to DTP antigens were also similar. The immunogenicity and safety of the PRP-T and DTP vaccines are equivalent when the vaccines are administered in separate syringes or the same syringe to infants. (J PEDIATR 1994;124:323-7).

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Immunogenicity and safety of Haemophilus influenzae type b-tetanus protein conjugate vaccine alone or mixed with diphtheria-tetanus-pertussis vaccine in infants

Abstract

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