Immunogenicity and safety of Haemophilus influenzae type b-tetanus protein conjugate vaccine alone or mixed with diphtheria-tetanus-pertussis vaccine in infants

Sheldon Kaplan, Brian A. Lauer, Mark A. Ward, Bernhard L. Wiedermann, Kenneth M. Boyer, Cindy M. Dukes, Don M. Schaffer, John Paisley, Robert Mendelson, Frank Pedreira, Bernard Fritzell

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Haemophilus capsular polysaccharide-tetanus toxoid conjugate (PRP-T) and diphtheria-tetanus-pertussis (DTP) vaccines were administered in a single syringe (group 1) or separate syringes (group 2) to 284 infants at 2, 4, and 6 months of age. Group 1 infants had a slightly greater incidence of local reactions. Systemic reactions were similar. The geometric mean titers of polyribosylribitol phosphate (PRP) serum antibody concentrations after the third dose of PRP-T vaccine were 4.8 and 4.3 μg/ml for groups 1 and 2, respectively. Antibody responses to DTP antigens were also similar. The immunogenicity and safety of the PRP-T and DTP vaccines are equivalent when the vaccines are administered in separate syringes or the same syringe to infants. (J PEDIATR 1994;124:323-7).

Original languageEnglish (US)
Pages (from-to)323-327
Number of pages5
JournalThe Journal of Pediatrics
Volume124
Issue number2
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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