Immunogenicity and efficacy of a measles virus-vectored chikungunya vaccine in nonhuman primates

Shannan L. Rossi, Jason E. Comer, Eryu Wang, Sasha R. Azar, William S. Lawrence, Jessica A. Plante, Katrin Ramsauer, Sabrina Schrauf, Scott C. Weaver

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    39 Scopus citations


    Background: Chikungunya virus (CHIKV) infection can result in chikungunya fever (CHIKF), a self-limited acute febrile illness that can progress to chronic arthralgic sequelae in a large percentage of patients. A new measles virus-vectored vaccine was developed to prevent CHIKF, and we tested it for immunogenicity and efficacy in a nonhuman primate model. Methods: Nine cynomolgus macaques were immunized and boosted with the measles virus-vectored chikungunya vaccine or sham-vaccinated. Sera were taken at multiple times during the vaccination phase to assess antibody responses against CHIKV. Macaques were challenged with a dose of CHIKV previously shown to cause fever and viremia, and core body temperature, viremia, and blood cell and chemistry panels were monitored. Results: The vaccine was well tolerated in all macaques, and all seroconverted (high neutralizing antibody [PRNT80 titers, 40-640] and enzyme-linked immunosorbent assay titers) after the boost. Furthermore, the vaccinated primates were protected against viremia, fever, elevated white blood cell counts, and CHIKF-associated cytokine changes after challenge with the virulent La Reunión CHIKV strain. Conclusions: These results further document the immunogenicity and efficacy of a measles-vectored chikungunya vaccine that shows promise in Phase I-II clinical trials. These findings are critical to human health because no vaccine to combat CHIKF is yet licensed.

    Original languageEnglish (US)
    Pages (from-to)735-742
    Number of pages8
    JournalJournal of Infectious Diseases
    Issue number5
    StatePublished - Jul 31 2019


    • Chikungunya virus
    • Measles virus
    • Nonhuman primate
    • Vaccine

    ASJC Scopus subject areas

    • Medicine(all)


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