Immunocytochemical studies on the localization of glucocorticoid receptor immunoreactive nerve cells in the lower brain stem and spinal cord of the male rat using a monoclonal antibody against rat liver glucocorticoid receptor

K. Fuxe, A. Härfstrand, L. F. Agnati, Z. Y. Yu, A. Cintra, A. C. Wikström, S. Okret, E. Cantoni, J. Å Gustafsson

Research output: Contribution to journalArticle

Abstract

By means of the indirect immunoperoxidase method glucocorticoid receptor (GR) immunoreactive nerve cells of the lower brain stem and the spinal cord have been mapped out in the rat, using a monoclonal antibody against rat liver GR. The GR immunoreactivity was predominantly located within the nuclei of these nerve cell bodies but also in glial cells of the gray and white matters. Strongly GR immunoreactive nerve cells were mainly found in the area of the noradrenaline, adrenaline and 5-hydroxytryptamine (5-HT) cell groups of the lower brain stem, and of the substantia gelatinosa of the nuc. tractus spinalis nervi trigemeni and spinal cord. The results suggest that glucocorticoids control transmitter and metabolic functions in discrete areas of the brain stem and spinal cord.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalNeuroscience Letters
Volume60
Issue number1
StatePublished - Sep 16 1985

Keywords

  • 5-hydroxytryptamine
  • brain stem
  • catecholamine
  • glucocorticoid receptor
  • nerve cell
  • rat
  • spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)

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