Immunocytochemical studies on the localization of glucocorticoid receptor immunoreactive nerve cells in the lower brain stem and spinal cord of the male rat using a monoclonal antibody against rat liver glucocorticoid receptor

K. Fuxe; A. Härfstrand; L. F. Agnati; Z. Y. Yu; A. Cintra; A. C. Wikström; S. Okret; E. Cantoni; J. Å Gustafsson

Immunocytochemical studies on the localization of glucocorticoid receptor immunoreactive nerve cells in the lower brain stem and spinal cord of the male rat using a monoclonal antibody against rat liver glucocorticoid receptor

K. Fuxe, A. Härfstrand, L. F. Agnati, Z. Y. Yu, A. Cintra, A. C. Wikström, S. Okret, E. Cantoni, J. Å Gustafsson

Research output: Contribution to journal › Article › peer-review

Abstract

By means of the indirect immunoperoxidase method glucocorticoid receptor (GR) immunoreactive nerve cells of the lower brain stem and the spinal cord have been mapped out in the rat, using a monoclonal antibody against rat liver GR. The GR immunoreactivity was predominantly located within the nuclei of these nerve cell bodies but also in glial cells of the gray and white matters. Strongly GR immunoreactive nerve cells were mainly found in the area of the noradrenaline, adrenaline and 5-hydroxytryptamine (5-HT) cell groups of the lower brain stem, and of the substantia gelatinosa of the nuc. tractus spinalis nervi trigemeni and spinal cord. The results suggest that glucocorticoids control transmitter and metabolic functions in discrete areas of the brain stem and spinal cord.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Neuroscience Letters
Volume	60
Issue number	1
State	Published - Sep 16 1985

Keywords

5-hydroxytryptamine
brain stem
catecholamine
glucocorticoid receptor
nerve cell
rat
spinal cord

ASJC Scopus subject areas

Neuroscience(all)

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Fuxe, K., Härfstrand, A., Agnati, L. F., Yu, Z. Y., Cintra, A., Wikström, A. C., Okret, S., Cantoni, E., & Gustafsson, J. Å. (1985). Immunocytochemical studies on the localization of glucocorticoid receptor immunoreactive nerve cells in the lower brain stem and spinal cord of the male rat using a monoclonal antibody against rat liver glucocorticoid receptor. Neuroscience Letters, 60(1), 1-6.

Immunocytochemical studies on the localization of glucocorticoid receptor immunoreactive nerve cells in the lower brain stem and spinal cord of the male rat using a monoclonal antibody against rat liver glucocorticoid receptor. / Fuxe, K.; Härfstrand, A.; Agnati, L. F. et al.

In: Neuroscience Letters, Vol. 60, No. 1, 16.09.1985, p. 1-6.

Research output: Contribution to journal › Article › peer-review

Fuxe, K, Härfstrand, A, Agnati, LF, Yu, ZY, Cintra, A, Wikström, AC, Okret, S, Cantoni, E & Gustafsson, JÅ 1985, 'Immunocytochemical studies on the localization of glucocorticoid receptor immunoreactive nerve cells in the lower brain stem and spinal cord of the male rat using a monoclonal antibody against rat liver glucocorticoid receptor', Neuroscience Letters, vol. 60, no. 1, pp. 1-6.

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abstract = "By means of the indirect immunoperoxidase method glucocorticoid receptor (GR) immunoreactive nerve cells of the lower brain stem and the spinal cord have been mapped out in the rat, using a monoclonal antibody against rat liver GR. The GR immunoreactivity was predominantly located within the nuclei of these nerve cell bodies but also in glial cells of the gray and white matters. Strongly GR immunoreactive nerve cells were mainly found in the area of the noradrenaline, adrenaline and 5-hydroxytryptamine (5-HT) cell groups of the lower brain stem, and of the substantia gelatinosa of the nuc. tractus spinalis nervi trigemeni and spinal cord. The results suggest that glucocorticoids control transmitter and metabolic functions in discrete areas of the brain stem and spinal cord.",

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AU - Härfstrand, A.

AU - Agnati, L. F.

AU - Yu, Z. Y.

AU - Cintra, A.

AU - Wikström, A. C.

AU - Okret, S.

AU - Cantoni, E.

AU - Gustafsson, J. Å

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AB - By means of the indirect immunoperoxidase method glucocorticoid receptor (GR) immunoreactive nerve cells of the lower brain stem and the spinal cord have been mapped out in the rat, using a monoclonal antibody against rat liver GR. The GR immunoreactivity was predominantly located within the nuclei of these nerve cell bodies but also in glial cells of the gray and white matters. Strongly GR immunoreactive nerve cells were mainly found in the area of the noradrenaline, adrenaline and 5-hydroxytryptamine (5-HT) cell groups of the lower brain stem, and of the substantia gelatinosa of the nuc. tractus spinalis nervi trigemeni and spinal cord. The results suggest that glucocorticoids control transmitter and metabolic functions in discrete areas of the brain stem and spinal cord.

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KW - brain stem

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KW - glucocorticoid receptor

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KW - spinal cord

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Immunocytochemical studies on the localization of glucocorticoid receptor immunoreactive nerve cells in the lower brain stem and spinal cord of the male rat using a monoclonal antibody against rat liver glucocorticoid receptor

Abstract

Keywords

ASJC Scopus subject areas

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