Immunocytochemical localization of glucocorticoid receptor in rat skin

T. Karstila, L. Rechardt, J. Honkaniemi, A. Karppinen, M. Pelto-Huikko, J. Å Gustafsson, A. C. Wikström

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations

    Abstract

    The aim of the present study was to map immunohistochemically the distribution of the glucocorticoid receptor (GR) in rat skin. Nuclear GR-like immunoreactivity (LI) was found in both epidermis and dermis. In the epidermis, the basal cell layer showed an intense immunoreaction; the lower part of the spinous layer was also labelled. In the dermis, the fibroblasts as well as the sweat glands, sebocytes and adipocytes were GR-immunoreactive (IR). In the root sheath of the hair follicle the staining was most intensive in the outer layer. The endothelial cells comprising the smooth muscle cells of the blood vessels, as well as the arrector pili muscle, showed GR-LI. In the peripheral nerves, the immunoreaction was localized to the nuclei of the Schwann cells and in the perineurial fibroblasts. Mast cells did not show nuclear GR-LI. Based on our immunocytochemical findings that several cell types of the skin are GR-IR, the variable physiological and pharmacological effects of glucocorticoids are easier to understand.

    Original languageEnglish (US)
    Pages (from-to)305-309
    Number of pages5
    JournalHistochemistry
    Volume102
    Issue number4
    DOIs
    StatePublished - Oct 1994

    ASJC Scopus subject areas

    • Anatomy
    • General Agricultural and Biological Sciences

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