Immune suppression by tumor-specific CD4+ regulatory T-cells in cancer

Research output: Contribution to journalReview article

56 Scopus citations


Regulatory T-cells play essential roles in inducing self-tolerance by suppressing immune responses against self such as autoantigens or non-self-antigens such as tumor and pathogenic antigens. Recent studies demonstrate the existence of CD4+ regulatory T-cells at tumor sites, implying that these Treg cells may induce antigen-specific and local immune tolerance. This review will discuss the natural ligands and their potential roles of tumor-specific CD4+ regulatory T-cells in cancer therapy.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalSeminars in Cancer Biology
Issue number1
StatePublished - Feb 2006


  • Antigen specificity
  • Immune suppression
  • Immunotherapy
  • Regulatory T cells
  • Toll-like receptors
  • Treg cells

ASJC Scopus subject areas

  • Cancer Research

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