Immune roles of dendritic cells in stem cell transplantation

Cheng Zhang, Wenwei Liao, Furong Liu, Xiaofeng Zhu, Xiaoshun He, Anbin Hu

Research output: Contribution to journalReview article

Abstract

Dendritic cells (DCs) are professional antigen-presenting cells and initial stimulators for immune response. DCs can shape their functions based on their immune states, which are crucial for the balance of immunity and tolerance to preserve homeostasis. In the immune response involved in stem cell transplantation, DCs also play important roles in inducing immune tolerance and antitumor immunity. After the rapid development of stem cell transplantation technology in recent years, the risks of graft rejection, tumor recurrence, and tumorigenicity are still present after stem cell transplantation. It is important to understand the mechanisms of DC-mediated immune tolerance and stimulation during stem cell transplantation. In this review, we will summarize and analyze the regulatory mechanisms of DCs in stem cell transplantation and their application in clinical settings. It may help to promote the innovation in basic theories and therapeutic approaches of stem cell transplantation.

Original languageEnglish (US)
Article numbere13090
JournalClinical Transplantation
Volume31
Issue number11
DOIs
StatePublished - Nov 1 2017

Keywords

  • antitumor immunity
  • dendritic cell
  • immune tolerance
  • stem cell
  • transplantation

ASJC Scopus subject areas

  • Transplantation

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