Immobilized Ferrous Ion and Glucose Oxidase on Graphdiyne and Its Application on One-Step Glucose Detection

Jiaming Liu, Xiaomei Shen, Didar Baimanov, Liming Wang, Yating Xiao, Huibiao Liu, Yuliang Li, Xingfa Gao, Yuliang Zhao, Chunying Chen

Research output: Contribution to journalArticlepeer-review

86 Scopus citations


Graphdiyne (GDY) is a novel two-dimensional (2D) carbon allotrope with sp-hybridized carbon atoms and hexagonal rings. Because of its unique structure and electronic property, GDY was reported as a promising candidate applied in energy storage, catalysis, biosensing and so on. However, using GDY as a platform to immobilize metal ion or enzyme was still not reported. Here, we presented a GDY-based composite with dual-enzyme activity by immobilizing ferrous ion and glucose oxidase onto GDY sheet. GDY showed great adsorption capacity and maintained the high catalytic activity of ferrous ion. The ferrous ion preferred to adsorb in between the neighboring two C-C triple bonds of GDY with lower adsorption energy (-5.64 eV) if compared to graphene (-1.69 eV). Meanwhile, GDY exhibited the ability of adsorbing glucose oxidase while did not obviously influence the structure and catalytic activity of the enzyme. The as-prepared composite was successfully used in one-step blood glucose detection. This work provides a new insight on ion and enzyme immobilization by 2D material.

Original languageEnglish (US)
Pages (from-to)2647-2654
Number of pages8
JournalACS Applied Materials and Interfaces
Issue number3
StatePublished - Jan 23 2019


  • enzyme immobilization
  • ferrous ion
  • glucose detection
  • glucose oxidase
  • graphdiyne

ASJC Scopus subject areas

  • Materials Science(all)


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