Imaging to Stratify Coronary Artery Disease Risk in Asymptomatic Patients with Diabetes

Research output: Contribution to journalReview article

Maan Malahfji, John J. Mahmarian

Coronary artery disease (CAD) is the leading cause of morbidity and mortality in patients with diabetes mellitus. Patients with diabetes have a higher prevalence of CAD and a larger magnitude of ischemia, and they are more likely to have silent myocardial ischemia and myocardial infarction. However, recent large cohort studies demonstrate that diabetic patients are not a homogenous group with similar high risk for cardiac events. In fact, more than 30% of asymptomatic diabetic patients do not have evidence of coronary atherosclerosis and have a very low annual cardiac event rate. Accordingly, there has been a recent paradigm shift as to whether the detection of subclinical coronary atherosclerosis through imaging can best guide therapeutic decision making. This review discusses the role of various cardiac imaging techniques for stratifying cardiovascular risk and optimizing therapy in asymptomatic diabetic patients.

Original languageEnglish (US)
Pages (from-to)266-272
Number of pages7
JournalMethodist DeBakey cardiovascular journal
Volume14
Issue number4
DOIs
StatePublished - Oct 1 2018

PMID: 30788012

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Imaging to Stratify Coronary Artery Disease Risk in Asymptomatic Patients with Diabetes. / Malahfji, Maan; Mahmarian, John J.

In: Methodist DeBakey cardiovascular journal, Vol. 14, No. 4, 01.10.2018, p. 266-272.

Research output: Contribution to journalReview article

Harvard

Malahfji, M & Mahmarian, JJ 2018, 'Imaging to Stratify Coronary Artery Disease Risk in Asymptomatic Patients with Diabetes' Methodist DeBakey cardiovascular journal, vol. 14, no. 4, pp. 266-272. https://doi.org/10.14797/mdcj-14-4-266

APA

Malahfji, M., & Mahmarian, J. J. (2018). Imaging to Stratify Coronary Artery Disease Risk in Asymptomatic Patients with Diabetes. Methodist DeBakey cardiovascular journal, 14(4), 266-272. https://doi.org/10.14797/mdcj-14-4-266

Vancouver

Malahfji M, Mahmarian JJ. Imaging to Stratify Coronary Artery Disease Risk in Asymptomatic Patients with Diabetes. Methodist DeBakey cardiovascular journal. 2018 Oct 1;14(4):266-272. https://doi.org/10.14797/mdcj-14-4-266

Author

Malahfji, Maan ; Mahmarian, John J. / Imaging to Stratify Coronary Artery Disease Risk in Asymptomatic Patients with Diabetes. In: Methodist DeBakey cardiovascular journal. 2018 ; Vol. 14, No. 4. pp. 266-272.

BibTeX

@article{c36dbd61664e4888970c0f5158ac9626,
title = "Imaging to Stratify Coronary Artery Disease Risk in Asymptomatic Patients with Diabetes",
abstract = "Coronary artery disease (CAD) is the leading cause of morbidity and mortality in patients with diabetes mellitus. Patients with diabetes have a higher prevalence of CAD and a larger magnitude of ischemia, and they are more likely to have silent myocardial ischemia and myocardial infarction. However, recent large cohort studies demonstrate that diabetic patients are not a homogenous group with similar high risk for cardiac events. In fact, more than 30{\%} of asymptomatic diabetic patients do not have evidence of coronary atherosclerosis and have a very low annual cardiac event rate. Accordingly, there has been a recent paradigm shift as to whether the detection of subclinical coronary atherosclerosis through imaging can best guide therapeutic decision making. This review discusses the role of various cardiac imaging techniques for stratifying cardiovascular risk and optimizing therapy in asymptomatic diabetic patients.",
keywords = "atherosclerosis, CACS, cardiac imaging, computed tomography coronary angiography, coronary artery calcium scoring, coronary artery disease, diabetes, myocardial ischemia",
author = "Maan Malahfji and Mahmarian, {John J.}",
year = "2018",
month = "10",
day = "1",
doi = "10.14797/mdcj-14-4-266",
language = "English (US)",
volume = "14",
pages = "266--272",
journal = "Methodist DeBakey Cardiovascular Journal",
issn = "1947-6094",
publisher = "Methodist DeBakey Heart & Vascular Center",
number = "4",

}

RIS

TY - JOUR

T1 - Imaging to Stratify Coronary Artery Disease Risk in Asymptomatic Patients with Diabetes

AU - Malahfji, Maan

AU - Mahmarian, John J.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Coronary artery disease (CAD) is the leading cause of morbidity and mortality in patients with diabetes mellitus. Patients with diabetes have a higher prevalence of CAD and a larger magnitude of ischemia, and they are more likely to have silent myocardial ischemia and myocardial infarction. However, recent large cohort studies demonstrate that diabetic patients are not a homogenous group with similar high risk for cardiac events. In fact, more than 30% of asymptomatic diabetic patients do not have evidence of coronary atherosclerosis and have a very low annual cardiac event rate. Accordingly, there has been a recent paradigm shift as to whether the detection of subclinical coronary atherosclerosis through imaging can best guide therapeutic decision making. This review discusses the role of various cardiac imaging techniques for stratifying cardiovascular risk and optimizing therapy in asymptomatic diabetic patients.

AB - Coronary artery disease (CAD) is the leading cause of morbidity and mortality in patients with diabetes mellitus. Patients with diabetes have a higher prevalence of CAD and a larger magnitude of ischemia, and they are more likely to have silent myocardial ischemia and myocardial infarction. However, recent large cohort studies demonstrate that diabetic patients are not a homogenous group with similar high risk for cardiac events. In fact, more than 30% of asymptomatic diabetic patients do not have evidence of coronary atherosclerosis and have a very low annual cardiac event rate. Accordingly, there has been a recent paradigm shift as to whether the detection of subclinical coronary atherosclerosis through imaging can best guide therapeutic decision making. This review discusses the role of various cardiac imaging techniques for stratifying cardiovascular risk and optimizing therapy in asymptomatic diabetic patients.

KW - atherosclerosis

KW - CACS

KW - cardiac imaging

KW - computed tomography coronary angiography

KW - coronary artery calcium scoring

KW - coronary artery disease

KW - diabetes

KW - myocardial ischemia

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U2 - 10.14797/mdcj-14-4-266

DO - 10.14797/mdcj-14-4-266

M3 - Review article

VL - 14

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EP - 272

JO - Methodist DeBakey Cardiovascular Journal

T2 - Methodist DeBakey Cardiovascular Journal

JF - Methodist DeBakey Cardiovascular Journal

SN - 1947-6094

IS - 4

ER -

ID: 46183146