Imaging of musculoskeletal manifestations in sickle cell disease patients

Vijaya Kosaraju, Alok Harwani, Sasan Partovi, Nicholas Bhojwani, Vasant Garg, Sabarish Ayyappan, Christos Kosmas, Mark Robbin

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Sickle cell disease (SCD) is a hereditary red cell disorder with clinical manifestations secondary to sickling or crescentshaped distortion of the red blood cells. Major clinical manifestations of SCD include haemolytic anaemia and vasoocclusive phenomena resulting in ischaemic tissue injury and organ damage. Chronic sequelae of the anaemia and vaso-occlusive processes involving the musculoskeletal system include complications related to extramedullary haematopoiesis, osteonecrosis, myonecrosis and osteomyelitis. Sickle cell bone disease is one of the commonest clinical presentations. Awareness and knowledge of the imaging features related to these complications are essential for early diagnosis and prompt management. In this article, the pathophysiology and key imaging findings related to these complications are reviewed.

Original languageEnglish (US)
Article number20160130
JournalBritish Journal of Radiology
Volume90
Issue number1073
DOIs
StatePublished - 2017

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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