Imaging high-intensity focused ultrasound-induced tissue denaturation by multispectral photoacoustic method: An ex vivo study

Yao Sun, Brian O'Neill

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We present an ex vivo study for the first time, to the best of our knowledge, in multispectral photoacoustic imaging (PAI) of tissue denaturation induced by high-intensity focused ultrasound (HIFU) in this paper. Tissue of bovine muscle was thermally treated in a heated water bath and by HIFU, and then was imaged using a multispectral photoacoustic approach. Light at multiple optical wavelengths between 700 and 900 nmwas delivered to the treated bovine muscle tissue to excite the photoacoustic signal. Apparent tissue denaturation has been observed in multispectral photoacoustic images after being treated in a water bath and by HIFU. It is interesting that the denaturation is more striking at shorter optical wavelength photoacoustic images than at longer optical wavelength photoacoustic images. Multispectral photoacoustic images of the tissue denaturation were further analyzed and the photoacoustic spectrums of the denaturized tissue were calculated in this paper. This study suggests that a multispectral PAI approachmight be a promising tool to evaluate tissue denaturation induced by HIFU treatment.

Original languageEnglish (US)
Pages (from-to)1764-1770
Number of pages7
JournalApplied Optics
Volume52
Issue number8
DOIs
StatePublished - Mar 10 2013

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering

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