Imaging extrastriatal dopamine D2 receptor occupancy by endogenous dopamine in healthy humans

Masahiro Fujita, N. Paul L.G. Verhoeff, Andrea Varrone, Sami S. Zoghbi, Ronald M. Baldwin, Peter A. Jatlow, George M. Anderson, John P. Seibyl, Robert B. Innis

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

The effect of endogenous dopamine on in vivo measurement of dopamine D2 receptors in extrastriatal regions (thalamus and temporal cortex) was evaluated with single photon emission computed tomography and the high affinity ligand [123I]epidepride by comparing the binding potential before and after acute dopamine depletion. Dopamine depletion was achieved by per- oral administration of 5.5 g/70 kg body weight α-methyl-para-tyrosine given in 37 h. The α-methyl-para-tyrosine treatment increased the binding potential significantly in the temporal cortex (13 ± 15%, P = 0.036) but not in the thalamus (2 ± 9%). The increase of the binding potential in the temporal cortex correlated strongly with the increase of dysphoric mood evaluated by the Positive and Negative Symptom Scale (PANSS) (ρ = 0.88, P = 0.004). These results imply that [123I]epidepride, coupled with acute dopamine depletion might provide estimates of synaptic dopamine concentration. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)179-188
Number of pages10
JournalEuropean Journal of Pharmacology
Volume387
Issue number2
DOIs
StatePublished - Jan 10 2000

Keywords

  • Binding, in vivo
  • Dopamine
  • Dopamine D receptor
  • Extrastriatal
  • SPECT (Single photon emission computed tomography)
  • Schizophrenia
  • [I]Epidepride
  • α-Methyl-para- tyrosine

ASJC Scopus subject areas

  • Pharmacology

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