Abstract
The effect of endogenous dopamine on in vivo measurement of dopamine D2 receptors in extrastriatal regions (thalamus and temporal cortex) was evaluated with single photon emission computed tomography and the high affinity ligand [123I]epidepride by comparing the binding potential before and after acute dopamine depletion. Dopamine depletion was achieved by per- oral administration of 5.5 g/70 kg body weight α-methyl-para-tyrosine given in 37 h. The α-methyl-para-tyrosine treatment increased the binding potential significantly in the temporal cortex (13 ± 15%, P = 0.036) but not in the thalamus (2 ± 9%). The increase of the binding potential in the temporal cortex correlated strongly with the increase of dysphoric mood evaluated by the Positive and Negative Symptom Scale (PANSS) (ρ = 0.88, P = 0.004). These results imply that [123I]epidepride, coupled with acute dopamine depletion might provide estimates of synaptic dopamine concentration. (C) 2000 Elsevier Science B.V.
Original language | English (US) |
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Pages (from-to) | 179-188 |
Number of pages | 10 |
Journal | European Journal of Pharmacology |
Volume | 387 |
Issue number | 2 |
DOIs | |
State | Published - Jan 10 2000 |
Keywords
- Binding, in vivo
- Dopamine
- Dopamine D receptor
- Extrastriatal
- SPECT (Single photon emission computed tomography)
- Schizophrenia
- [I]Epidepride
- α-Methyl-para- tyrosine
ASJC Scopus subject areas
- Pharmacology