IgG4-related disease in a non-healing gastric ulcer: Case report

Amanda B. Moyer, Mary R. Schwartz, Sherry Lim, Matthew L. Tompson, Jae Y. Ro

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


We report a 28-year-old woman with a refractory gastric ulcer in the absence of Helicobacter pylori infection and autoimmune pancreatitis. Histologic examination of the gastric ulcer demonstrated abundant IgG4 positive plasma cells populating a lymphoplasmacytic infiltrate with associated sclerosis. Our case suggests that treatment-refractory peptic ulcer may be related to IgG4-related inflammation. When a biopsy performed to evaluate a refractory ulcer reveals abundant plasma cells and sclerotic fibrosis, an immunohistochemical stain for IgG4 and serum IgG4 measurement might be considered.

Original languageEnglish (US)
Pages (from-to)6588-6591
Number of pages4
JournalInternational journal of clinical and experimental pathology
Issue number6
StatePublished - 2016


  • Gastric ulcer
  • IgG4

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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