We report a 28-year-old woman with a refractory gastric ulcer in the absence of Helicobacter pylori infection and autoimmune pancreatitis. Histologic examination of the gastric ulcer demonstrated abundant IgG4 positive plasma cells populating a lymphoplasmacytic infiltrate with associated sclerosis. Our case suggests that treatment-refractory peptic ulcer may be related to IgG4-related inflammation. When a biopsy performed to evaluate a refractory ulcer reveals abundant plasma cells and sclerotic fibrosis, an immunohistochemical stain for IgG4 and serum IgG4 measurement might be considered.
|Original language||English (US)|
|Number of pages||4|
|Journal||International journal of clinical and experimental pathology|
|State||Published - 2016|
- Gastric ulcer
ASJC Scopus subject areas
- Pathology and Forensic Medicine