Igg Reactivity in the Spinal Cord and Motor Cortex in Amyotrophic Lateral Sclerosis

Jozsef I. Engelhardt, Stanley H. Appel

Research output: Contribution to journalArticlepeer-review

172 Scopus citations

Abstract

The spinal cord and motor cortex of patients with amyotrophic lateral sclerosis (ALS) were examined and immunohistochemical methods for the presence of IgG. In 13 of 15 spinal cords, a population of motoneurons stained positively for IgG in a granular pattern, characteristic of binding to the rough endoplasmic reticulum. In 6 of 11 motor cortices, a proportion of pyramidal cells also stained positively for IgG. No such reactivity was noted in motoneurons of control human tissues, although positive IgG staining was present in astrocytes of ALS and control specimens. Reactive microglia and/or macrophages were detected in the territory of degenerating pyramidal tracts and ventral horns. The surface of most of these cells stained positively for IgG, and 50% stained positively for HLA-DR. The accumulation of IgG in motoneurons and the presence of immunologically active macrophages provide additional evidence for the participation of immunologic factors in the pathogenesis of ALS.

Original languageEnglish (US)
Pages (from-to)1210-1216
Number of pages7
JournalArchives of neurology
Volume47
Issue number11
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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