Identification of two murine loci homologous to the v-cbl oncogene

D. C. Regnier, C. A. Kozak, D. M. Kingsley, N. A. Jenkins, N. G. Copeland, W. Y. Langdon, H. C. Morse

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The virally transduced oncogene v-cbl transforms fibroblasts in vitro and induces early B-cell-lineage lymphomas in vivo. A series of probes derived from a molecular clone of v-cbl were used to map related sequences in the mouse genome. Analyses of Chinese hamster x mouse somatic-cell hybrids showed that two related genes, cbl-1 and cbl-2, were located on chromosomes 6 and 9, respectively. Restriction enzyme studies of DNA from hybrid cells containing either chromosome 6 or 9 suggested that cbl-1 resembles v-cbl and may be a processed gene, whereas cbl-2 has a complex genomic structure. Analyses of Mus domesticus/M. spretus interspecific backcross mice showed that Cbl-1 maps between the immunoglobulin kappa light chain and T-cell receptor beta chain loci and that Cbl-2 is tightly linked to Thy-1.

Original languageEnglish (US)
Pages (from-to)3678-3682
Number of pages5
JournalJournal of virology
Volume63
Issue number9
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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