Identification of target organs of copper nanoparticles with ICP-MS technique

Zhen Chen, Huan Meng, Hui Yuan, Gengmei Xing, Chunying Chen, Feng Zhao, Yun Wang, Chengcheng Zhang, Yuliang Zhao

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Nanosized copper particles are widely used in fields of lubricants, polymers/plastic, metallic coating and ink. Recently, we found that copper particles in different sizes can lead to different toxicological effects. To clarify the target organs of copper particles of different sizes, the inductively coupled plasma mass spectroscopy (ICP-MS) was employed to evaluate the distribution of copper in different organs of mice after a single dose oral exposure. The results suggest that the main target organs for copper nanoparticles are kidney, liver and blood. Liver is the main damaged organ.

Original languageEnglish (US)
Pages (from-to)599-603
Number of pages5
JournalJournal of Radioanalytical and Nuclear Chemistry
Issue number3
StatePublished - Jun 2007

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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