Identification of target organs of copper nanoparticles with ICP-MS technique

Zhen Chen; Huan Meng; Hui Yuan; Gengmei Xing; Chunying Chen; Feng Zhao; Yun Wang; Chengcheng Zhang; Yuliang Zhao

doi:10.1007/s10967-007-0631-1

Identification of target organs of copper nanoparticles with ICP-MS technique

Zhen Chen, Huan Meng, Hui Yuan, Gengmei Xing, Chunying Chen, Feng Zhao, Yun Wang, Chengcheng Zhang, Yuliang Zhao

Houston Methodist

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Nanosized copper particles are widely used in fields of lubricants, polymers/plastic, metallic coating and ink. Recently, we found that copper particles in different sizes can lead to different toxicological effects. To clarify the target organs of copper particles of different sizes, the inductively coupled plasma mass spectroscopy (ICP-MS) was employed to evaluate the distribution of copper in different organs of mice after a single dose oral exposure. The results suggest that the main target organs for copper nanoparticles are kidney, liver and blood. Liver is the main damaged organ.

Original language	English (US)
Pages (from-to)	599-603
Number of pages	5
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	272
Issue number	3
DOIs	https://doi.org/10.1007/s10967-007-0631-1
State	Published - Jun 2007

ASJC Scopus subject areas

Analytical Chemistry
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Pollution
Spectroscopy
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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title = "Identification of target organs of copper nanoparticles with ICP-MS technique",

abstract = "Nanosized copper particles are widely used in fields of lubricants, polymers/plastic, metallic coating and ink. Recently, we found that copper particles in different sizes can lead to different toxicological effects. To clarify the target organs of copper particles of different sizes, the inductively coupled plasma mass spectroscopy (ICP-MS) was employed to evaluate the distribution of copper in different organs of mice after a single dose oral exposure. The results suggest that the main target organs for copper nanoparticles are kidney, liver and blood. Liver is the main damaged organ.",

author = "Zhen Chen and Huan Meng and Hui Yuan and Gengmei Xing and Chunying Chen and Feng Zhao and Yun Wang and Chengcheng Zhang and Yuliang Zhao",

note = "Funding Information: We acknowledge funding support from the Chinese National Natural Science Foundation (10675141), the National Science Fund for Distinguished Young Scholars (10525524), the Ministry of Science and Technology (2006CB705601). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

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T1 - Identification of target organs of copper nanoparticles with ICP-MS technique

AU - Chen, Zhen

AU - Meng, Huan

AU - Yuan, Hui

AU - Xing, Gengmei

AU - Chen, Chunying

AU - Zhao, Feng

AU - Wang, Yun

AU - Zhang, Chengcheng

AU - Zhao, Yuliang

N1 - Funding Information: We acknowledge funding support from the Chinese National Natural Science Foundation (10675141), the National Science Fund for Distinguished Young Scholars (10525524), the Ministry of Science and Technology (2006CB705601). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2007/6

Y1 - 2007/6

N2 - Nanosized copper particles are widely used in fields of lubricants, polymers/plastic, metallic coating and ink. Recently, we found that copper particles in different sizes can lead to different toxicological effects. To clarify the target organs of copper particles of different sizes, the inductively coupled plasma mass spectroscopy (ICP-MS) was employed to evaluate the distribution of copper in different organs of mice after a single dose oral exposure. The results suggest that the main target organs for copper nanoparticles are kidney, liver and blood. Liver is the main damaged organ.

AB - Nanosized copper particles are widely used in fields of lubricants, polymers/plastic, metallic coating and ink. Recently, we found that copper particles in different sizes can lead to different toxicological effects. To clarify the target organs of copper particles of different sizes, the inductively coupled plasma mass spectroscopy (ICP-MS) was employed to evaluate the distribution of copper in different organs of mice after a single dose oral exposure. The results suggest that the main target organs for copper nanoparticles are kidney, liver and blood. Liver is the main damaged organ.

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Identification of target organs of copper nanoparticles with ICP-MS technique

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