TY - JOUR
T1 - Identification of target organs of copper nanoparticles with ICP-MS technique
AU - Chen, Zhen
AU - Meng, Huan
AU - Yuan, Hui
AU - Xing, Gengmei
AU - Chen, Chunying
AU - Zhao, Feng
AU - Wang, Yun
AU - Zhang, Chengcheng
AU - Zhao, Yuliang
N1 - Funding Information:
We acknowledge funding support from the Chinese National Natural Science Foundation (10675141), the National Science Fund for Distinguished Young Scholars (10525524), the Ministry of Science and Technology (2006CB705601).
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/6
Y1 - 2007/6
N2 - Nanosized copper particles are widely used in fields of lubricants, polymers/plastic, metallic coating and ink. Recently, we found that copper particles in different sizes can lead to different toxicological effects. To clarify the target organs of copper particles of different sizes, the inductively coupled plasma mass spectroscopy (ICP-MS) was employed to evaluate the distribution of copper in different organs of mice after a single dose oral exposure. The results suggest that the main target organs for copper nanoparticles are kidney, liver and blood. Liver is the main damaged organ.
AB - Nanosized copper particles are widely used in fields of lubricants, polymers/plastic, metallic coating and ink. Recently, we found that copper particles in different sizes can lead to different toxicological effects. To clarify the target organs of copper particles of different sizes, the inductively coupled plasma mass spectroscopy (ICP-MS) was employed to evaluate the distribution of copper in different organs of mice after a single dose oral exposure. The results suggest that the main target organs for copper nanoparticles are kidney, liver and blood. Liver is the main damaged organ.
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U2 - 10.1007/s10967-007-0631-1
DO - 10.1007/s10967-007-0631-1
M3 - Article
AN - SCOPUS:34247635628
VL - 272
SP - 599
EP - 603
JO - Journal of Radioanalytical and Nuclear Chemistry
JF - Journal of Radioanalytical and Nuclear Chemistry
SN - 0236-5731
IS - 3
ER -