Identification of srv, A PrfA-Like Regulator of Group A Streptococcus That Influences Virulence

Sean D. Reid; Alison G. Montgomery; James M. Musser

doi:10.1128/IAI.72.3.1799-1803.2004

Identification of srv, A PrfA-Like Regulator of Group A Streptococcus That Influences Virulence

Sean D. Reid, Alison G. Montgomery, James M. Musser

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23 Scopus citations

Abstract

We have identified a Crp/Fnr-like transcriptional regulator of Streptococcus pyogenes that when inactivated attenuates virulence. The gene, named srv for streptococcal regulator of virulence, encodes a 240-amino-acid protein with 53% amino acid similarity to PrfA, a transcriptional activator of virulence in Listeria monocytogenes.

Original language	English (US)
Pages (from-to)	1799-1803
Number of pages	5
Journal	Infection and Immunity
Volume	72
Issue number	3
DOIs	https://doi.org/10.1128/IAI.72.3.1799-1803.2004
State	Published - Mar 2004

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.72.3.1799-1803.2004

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title = "Identification of srv, A PrfA-Like Regulator of Group A Streptococcus That Influences Virulence",

abstract = "We have identified a Crp/Fnr-like transcriptional regulator of Streptococcus pyogenes that when inactivated attenuates virulence. The gene, named srv for streptococcal regulator of virulence, encodes a 240-amino-acid protein with 53\% amino acid similarity to PrfA, a transcriptional activator of virulence in Listeria monocytogenes.",

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N2 - We have identified a Crp/Fnr-like transcriptional regulator of Streptococcus pyogenes that when inactivated attenuates virulence. The gene, named srv for streptococcal regulator of virulence, encodes a 240-amino-acid protein with 53% amino acid similarity to PrfA, a transcriptional activator of virulence in Listeria monocytogenes.

AB - We have identified a Crp/Fnr-like transcriptional regulator of Streptococcus pyogenes that when inactivated attenuates virulence. The gene, named srv for streptococcal regulator of virulence, encodes a 240-amino-acid protein with 53% amino acid similarity to PrfA, a transcriptional activator of virulence in Listeria monocytogenes.

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DO - 10.1128/IAI.72.3.1799-1803.2004

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AN - SCOPUS:1342344893

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Identification of srv, A PrfA-Like Regulator of Group A Streptococcus That Influences Virulence

Abstract

ASJC Scopus subject areas

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