Identification of srv, A PrfA-Like Regulator of Group A Streptococcus That Influences Virulence

Sean D. Reid, Alison G. Montgomery, James M. Musser

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

We have identified a Crp/Fnr-like transcriptional regulator of Streptococcus pyogenes that when inactivated attenuates virulence. The gene, named srv for streptococcal regulator of virulence, encodes a 240-amino-acid protein with 53% amino acid similarity to PrfA, a transcriptional activator of virulence in Listeria monocytogenes.

Original languageEnglish (US)
Pages (from-to)1799-1803
Number of pages5
JournalInfection and Immunity
Volume72
Issue number3
DOIs
StatePublished - Mar 2004

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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