Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia

Zakia Al-Lamki; Yasser A. Wali; Shah M. Wasifuddin; Mathew Zachariah; Rayhanah Al-Mjeni; Changping Li; Shanmugakonar Muralitharan; Khalsa Al-Kharusi; Preethi Gunaratne; Leif E. Peterson; Richard Gibbs; Marie Claude Gingras; Judith F. Margolin

doi:10.1080/08880010500199069

Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia

Zakia Al-Lamki, Yasser A. Wali, Shah M. Wasifuddin, Mathew Zachariah, Rayhanah Al-Mjeni, Changping Li, Shanmugakonar Muralitharan, Khalsa Al-Kharusi, Preethi Gunaratne, Leif E. Peterson, Richard Gibbs, Marie Claude Gingras, Judith F. Margolin

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.

Original language	English (US)
Pages (from-to)	629-643
Number of pages	15
Journal	Pediatric Hematology and Oncology
Volume	22
Issue number	7
DOIs	https://doi.org/10.1080/08880010500199069
State	Published - Oct 2005

Keywords

ALL
CASK
CRSP2
Gene expression profiling
GZMK

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology
Cancer Research

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10.1080/08880010500199069

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Al-Lamki, Z., Wali, Y. A., Wasifuddin, S. M., Zachariah, M., Al-Mjeni, R., Li, C., Muralitharan, S., Al-Kharusi, K., Gunaratne, P., Peterson, L. E., Gibbs, R., Gingras, M. C., & Margolin, J. F. (2005). Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia. Pediatric Hematology and Oncology, 22(7), 629-643. https://doi.org/10.1080/08880010500199069

Al-Lamki, Z, Wali, YA, Wasifuddin, SM, Zachariah, M, Al-Mjeni, R, Li, C, Muralitharan, S, Al-Kharusi, K, Gunaratne, P, Peterson, LE, Gibbs, R, Gingras, MC & Margolin, JF 2005, 'Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia', Pediatric Hematology and Oncology, vol. 22, no. 7, pp. 629-643. https://doi.org/10.1080/08880010500199069

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title = "Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia",

abstract = "Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.",

keywords = "ALL, CASK, CRSP2, Gene expression profiling, GZMK",

author = "Zakia Al-Lamki and Wali, \{Yasser A.\} and Wasifuddin, \{Shah M.\} and Mathew Zachariah and Rayhanah Al-Mjeni and Changping Li and Shanmugakonar Muralitharan and Khalsa Al-Kharusi and Preethi Gunaratne and Peterson, \{Leif E.\} and Richard Gibbs and Gingras, \{Marie Claude\} and Margolin, \{Judith F.\}",

year = "2005",

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doi = "10.1080/08880010500199069",

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AU - Wali, Yasser A.

AU - Wasifuddin, Shah M.

AU - Zachariah, Mathew

AU - Al-Mjeni, Rayhanah

AU - Li, Changping

AU - Muralitharan, Shanmugakonar

AU - Al-Kharusi, Khalsa

AU - Gunaratne, Preethi

AU - Peterson, Leif E.

AU - Gibbs, Richard

AU - Gingras, Marie Claude

AU - Margolin, Judith F.

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AB - Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.

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Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia

Abstract

Keywords

ASJC Scopus subject areas

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