Identification of mammalian noggin and its expression in the adult nervous system

David M. Valenzuela, Aris N. Economides, Eduardo Rojas, Teresa M. Lamb, Lorna Nuñez, Pam Jones, Nancy Y. Ip, Rafael Espinosa, Camilynn I. Brannan, Debra J. Gilbert, Neal G. Copeland, Nancy A. Jenkins, Michelle M. Le Beau, Richard M. Harland, George D. Yancopoulos

Research output: Contribution to journalArticlepeer-review

121 Scopus citations


The multiple roles of noggin during dorsal fate specification in Xenopus embryos, together with noggin's ability to directly induce neural tissue, inspired an effort to determine whether a similar molecule exists in mammals. Here we describe the identification of human and rat noggin and explore their expression patterns; we also localize the human NOGGIN gene to chromosome 17q22, and the mouse gene to a syntenic region of chromosome 11. Mammalian noggin is remarkably similar in its sequence to Xenopus noggin, and is similarly active in induction assays performed on Xenopus embryo tissues. In the adult mammal, noggin is most notably expressed in particular regions of the nervous system, such as the tufted cells of the olfactory bulb, the piriform cortex of the brain, and the Purkinje cells of the cerebellum, suggesting that one of the earliest acting neural inducers also has important roles in the adult nervous system.

Original languageEnglish (US)
Pages (from-to)6077-6084
Number of pages8
JournalJournal of Neuroscience
Issue number9
StatePublished - Sep 1995


  • dorsalization
  • neural inducer
  • Nieuwkoop center
  • noggin
  • olfactory bulb
  • Purkinje cells
  • Spemann organizer

ASJC Scopus subject areas

  • Neuroscience(all)


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