Abstract
Using single-molecule force measurement and fluorescence imaging, we have demonstrated that luteolin has an inhibitory effect on IGF-1 ligand-receptor binding, the initial step in IGF-1 signaling. This inhibition mechanism, which was confirmed by flow cytometry and molecular docking, could play a role in cancer therapy.
Original language | English (US) |
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Pages (from-to) | 929-933 |
Number of pages | 5 |
Journal | ChemBioChem |
Volume | 14 |
Issue number | 8 |
DOIs | |
State | Published - May 27 2013 |
Keywords
- Fluorescence
- Insulin-like growth factor 1
- Luteolin
- Receptors
- Single-molecule force measurement
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Molecular Medicine
- Molecular Biology