Identification of an Inhibitory Mechanism of Luteolin on the Insulin-Like Growth Factor-1 Ligand-Receptor Interaction

Yong Yang; Jianliang Shen; Xujiang Yu; Guoting Qin; Mingzhen Zhang; Haifa Shen; Zongwan Mao; Mauro Ferrari

doi:10.1002/cbic.201300082

Identification of an Inhibitory Mechanism of Luteolin on the Insulin-Like Growth Factor-1 Ligand-Receptor Interaction

Yong Yang, Jianliang Shen, Xujiang Yu, Guoting Qin, Mingzhen Zhang, Haifa Shen, Zongwan Mao, Mauro Ferrari

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Using single-molecule force measurement and fluorescence imaging, we have demonstrated that luteolin has an inhibitory effect on IGF-1 ligand-receptor binding, the initial step in IGF-1 signaling. This inhibition mechanism, which was confirmed by flow cytometry and molecular docking, could play a role in cancer therapy.

Original language	English (US)
Pages (from-to)	929-933
Number of pages	5
Journal	ChemBioChem
Volume	14
Issue number	8
DOIs	https://doi.org/10.1002/cbic.201300082
State	Published - May 27 2013

Keywords

Fluorescence
Insulin-like growth factor 1
Luteolin
Receptors
Single-molecule force measurement

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Molecular Medicine
Molecular Biology

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10.1002/cbic.201300082

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abstract = "Using single-molecule force measurement and fluorescence imaging, we have demonstrated that luteolin has an inhibitory effect on IGF-1 ligand-receptor binding, the initial step in IGF-1 signaling. This inhibition mechanism, which was confirmed by flow cytometry and molecular docking, could play a role in cancer therapy.",

keywords = "Fluorescence, Insulin-like growth factor 1, Luteolin, Receptors, Single-molecule force measurement",

author = "Yong Yang and Jianliang Shen and Xujiang Yu and Guoting Qin and Mingzhen Zhang and Haifa Shen and Zongwan Mao and Mauro Ferrari",

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AU - Yang, Yong

AU - Shen, Jianliang

AU - Yu, Xujiang

AU - Qin, Guoting

AU - Zhang, Mingzhen

AU - Shen, Haifa

AU - Mao, Zongwan

AU - Ferrari, Mauro

PY - 2013/5/27

Y1 - 2013/5/27

N2 - Using single-molecule force measurement and fluorescence imaging, we have demonstrated that luteolin has an inhibitory effect on IGF-1 ligand-receptor binding, the initial step in IGF-1 signaling. This inhibition mechanism, which was confirmed by flow cytometry and molecular docking, could play a role in cancer therapy.

AB - Using single-molecule force measurement and fluorescence imaging, we have demonstrated that luteolin has an inhibitory effect on IGF-1 ligand-receptor binding, the initial step in IGF-1 signaling. This inhibition mechanism, which was confirmed by flow cytometry and molecular docking, could play a role in cancer therapy.

KW - Fluorescence

KW - Insulin-like growth factor 1

KW - Luteolin

KW - Receptors

KW - Single-molecule force measurement

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Identification of an Inhibitory Mechanism of Luteolin on the Insulin-Like Growth Factor-1 Ligand-Receptor Interaction

Abstract

Keywords

ASJC Scopus subject areas

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