Identification of an Inhibitory Mechanism of Luteolin on the Insulin-Like Growth Factor-1 Ligand-Receptor Interaction

Yong Yang, Jianliang Shen, Xujiang Yu, Guoting Qin, Mingzhen Zhang, Haifa Shen, Zongwan Mao, Mauro Ferrari

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Using single-molecule force measurement and fluorescence imaging, we have demonstrated that luteolin has an inhibitory effect on IGF-1 ligand-receptor binding, the initial step in IGF-1 signaling. This inhibition mechanism, which was confirmed by flow cytometry and molecular docking, could play a role in cancer therapy.

Original languageEnglish (US)
Pages (from-to)929-933
Number of pages5
JournalChemBioChem
Volume14
Issue number8
DOIs
StatePublished - May 27 2013

Keywords

  • Fluorescence
  • Insulin-like growth factor 1
  • Luteolin
  • Receptors
  • Single-molecule force measurement

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology

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