TY - JOUR
T1 - Identification of an Aptamer With Binding Specificity to Tumor-Homing Myeloid-Derived Suppressor Cells
AU - Tian, Shaohui
AU - Welte, Thomas
AU - Mai, Junhua
AU - Liu, Yongbin
AU - Ramirez, Maricela
AU - Shen, Haifa
N1 - Funding Information:
This work was partially supported by the National Institute of Health grants R01CA222959 and U54CA210181.
Publisher Copyright:
Copyright © 2022 Tian, Welte, Mai, Liu, Ramirez and Shen.
PY - 2022/1/21
Y1 - 2022/1/21
N2 - Myeloid-derived suppressor cells (MDSCs) play a critical role in tumor growth and metastasis. Since they constantly infiltrate into the tumor tissue, these cells are considered as an ideal carrier for tumor-targeted drug delivery. We recently identified a DNA-based thioaptamer (T1) with tumor accumulating activity, demonstrated its potential on tumor targeting and drug delivery. In the current study, we have carried out structure-activity relationship analysis to further optimize the aptamer. In the process, we have identified a sequence-modified aptamer (M1) that shows an enhanced binding affinity to MDSCs over the parental T1 aptamer. In addition, M1 can penetrate into the tumor tissue more effectively by hitchhiking on MDSCs. Taken together, we have identified a new reagent for enhanced tumor-targeted drug delivery.
AB - Myeloid-derived suppressor cells (MDSCs) play a critical role in tumor growth and metastasis. Since they constantly infiltrate into the tumor tissue, these cells are considered as an ideal carrier for tumor-targeted drug delivery. We recently identified a DNA-based thioaptamer (T1) with tumor accumulating activity, demonstrated its potential on tumor targeting and drug delivery. In the current study, we have carried out structure-activity relationship analysis to further optimize the aptamer. In the process, we have identified a sequence-modified aptamer (M1) that shows an enhanced binding affinity to MDSCs over the parental T1 aptamer. In addition, M1 can penetrate into the tumor tissue more effectively by hitchhiking on MDSCs. Taken together, we have identified a new reagent for enhanced tumor-targeted drug delivery.
KW - G-quadruplex
KW - aptamer
KW - myeloid-derived suppressor cell
KW - structure-activity relationship
KW - tumor-targeted delivery
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U2 - 10.3389/fphar.2021.752934
DO - 10.3389/fphar.2021.752934
M3 - Article
C2 - 35126104
AN - SCOPUS:85124071037
SN - 1663-9812
VL - 12
SP - 752934
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 752934
ER -