Abstract
The impurity in commercial diphenylamine which induces polycystic kidney disease in rats has been identified as N, N, N’-tri-phenyl-p-phenylenediamine. The structure of the compound was confirmed by mass and proton magnetic resonance spectrometry and by comparison with a synthetic standard prepared by the Ullman coupling of iodobenzene and p-phenylenediamine or N, N-diphenyl-p-phenylene-diamine. Laboratory studies with highly purified diphenylamine indicated that N, N, N’-triphenyl-p-phenylenediamine can be formed by heating diphenylamine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 125-130 |
| Number of pages | 6 |
| Journal | Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1981 |
Keywords
- N
- N’
- diphenylamine N
- tryphenyl-p-phenylenediamine toxic impurity kidney disease
ASJC Scopus subject areas
- Food Science
- Pollution
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