Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)

Wei Wang; Hortensia Soto; Elizabeth R. Oldham; Matthew E. Buchanan; Bernhard Homey; Daniel Catron; Nancy Jenkins; Neal G. Copeland; Debra J. Gilbert; Nhung Nguyen; John Abrams; David Kershenovich; Kathleen Smith; Terri McClanahan; Alain P. Vicari; Albert Zlotnik

doi:10.1074/jbc.M001461200

Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)

Wei Wang, Hortensia Soto, Elizabeth R. Oldham, Matthew E. Buchanan, Bernhard Homey, Daniel Catron, Nancy Jenkins, Neal G. Copeland, Debra J. Gilbert, Nhung Nguyen, John Abrams, David Kershenovich, Kathleen Smith, Terri McClanahan, Alain P. Vicari, Albert Zlotnik

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244 Scopus citations

Abstract

We report the identification and characterization of a novel CC chemokine designated CCL28 and its receptor CCR10, known previously as orphan G-protein-coupled receptor GPR2. Human and mouse CCL28 share 83% identity at the amino acid and 76% at the nucleic acid levels. We also identified the mouse homologues of CCL28 and of CCR10, which map to mouse chromosomes 13 and 11, respectively. CCL28 is expressed in a variety of human and mouse tissues, and it appears to be predominantly produced by epithelial cells. Both human and mouse CCL28 induce calcium mobilization in human and mouse CCR10-expressing transfectants. CCL28 desensitized the calcium mobilization induced in CCR10 transfectants by CCL27, indicating that these chemokines share this new chemokine receptor. In vitro, recombinant human CCL28 displays chemotactic activity for resting CD4 or CD8 T cells.

Original language	English (US)
Pages (from-to)	22313-22323
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	275
Issue number	29
DOIs	https://doi.org/10.1074/jbc.M001461200
State	Published - Jul 21 2000

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Wang, W., Soto, H., Oldham, E. R., Buchanan, M. E., Homey, B., Catron, D., Jenkins, N., Copeland, N. G., Gilbert, D. J., Nguyen, N., Abrams, J., Kershenovich, D., Smith, K., McClanahan, T., Vicari, A. P., & Zlotnik, A. (2000). Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). Journal of Biological Chemistry, 275(29), 22313-22323. https://doi.org/10.1074/jbc.M001461200

Wang, W, Soto, H, Oldham, ER, Buchanan, ME, Homey, B, Catron, D, Jenkins, N , Copeland, NG, Gilbert, DJ, Nguyen, N, Abrams, J, Kershenovich, D, Smith, K, McClanahan, T, Vicari, AP & Zlotnik, A 2000, 'Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)', Journal of Biological Chemistry, vol. 275, no. 29, pp. 22313-22323. https://doi.org/10.1074/jbc.M001461200

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abstract = "We report the identification and characterization of a novel CC chemokine designated CCL28 and its receptor CCR10, known previously as orphan G-protein-coupled receptor GPR2. Human and mouse CCL28 share 83% identity at the amino acid and 76% at the nucleic acid levels. We also identified the mouse homologues of CCL28 and of CCR10, which map to mouse chromosomes 13 and 11, respectively. CCL28 is expressed in a variety of human and mouse tissues, and it appears to be predominantly produced by epithelial cells. Both human and mouse CCL28 induce calcium mobilization in human and mouse CCR10-expressing transfectants. CCL28 desensitized the calcium mobilization induced in CCR10 transfectants by CCL27, indicating that these chemokines share this new chemokine receptor. In vitro, recombinant human CCL28 displays chemotactic activity for resting CD4 or CD8 T cells.",

author = "Wei Wang and Hortensia Soto and Oldham, {Elizabeth R.} and Buchanan, {Matthew E.} and Bernhard Homey and Daniel Catron and Nancy Jenkins and Copeland, {Neal G.} and Gilbert, {Debra J.} and Nhung Nguyen and John Abrams and David Kershenovich and Kathleen Smith and Terri McClanahan and Vicari, {Alain P.} and Albert Zlotnik",

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doi = "10.1074/jbc.M001461200",

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AU - Soto, Hortensia

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AU - Buchanan, Matthew E.

AU - Homey, Bernhard

AU - Catron, Daniel

AU - Jenkins, Nancy

AU - Copeland, Neal G.

AU - Gilbert, Debra J.

AU - Nguyen, Nhung

AU - Abrams, John

AU - Kershenovich, David

AU - Smith, Kathleen

AU - McClanahan, Terri

AU - Vicari, Alain P.

AU - Zlotnik, Albert

PY - 2000/7/21

Y1 - 2000/7/21

N2 - We report the identification and characterization of a novel CC chemokine designated CCL28 and its receptor CCR10, known previously as orphan G-protein-coupled receptor GPR2. Human and mouse CCL28 share 83% identity at the amino acid and 76% at the nucleic acid levels. We also identified the mouse homologues of CCL28 and of CCR10, which map to mouse chromosomes 13 and 11, respectively. CCL28 is expressed in a variety of human and mouse tissues, and it appears to be predominantly produced by epithelial cells. Both human and mouse CCL28 induce calcium mobilization in human and mouse CCR10-expressing transfectants. CCL28 desensitized the calcium mobilization induced in CCR10 transfectants by CCL27, indicating that these chemokines share this new chemokine receptor. In vitro, recombinant human CCL28 displays chemotactic activity for resting CD4 or CD8 T cells.

AB - We report the identification and characterization of a novel CC chemokine designated CCL28 and its receptor CCR10, known previously as orphan G-protein-coupled receptor GPR2. Human and mouse CCL28 share 83% identity at the amino acid and 76% at the nucleic acid levels. We also identified the mouse homologues of CCL28 and of CCR10, which map to mouse chromosomes 13 and 11, respectively. CCL28 is expressed in a variety of human and mouse tissues, and it appears to be predominantly produced by epithelial cells. Both human and mouse CCL28 induce calcium mobilization in human and mouse CCR10-expressing transfectants. CCL28 desensitized the calcium mobilization induced in CCR10 transfectants by CCL27, indicating that these chemokines share this new chemokine receptor. In vitro, recombinant human CCL28 displays chemotactic activity for resting CD4 or CD8 T cells.

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Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)

Abstract

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