Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors

M. L. Mucenski, B. A. Taylor, J. N. Ihle, J. W. Hartley, H. C. Morse, N. A. Jenkins, N. G. Copeland

Research output: Contribution to journalArticlepeer-review

171 Scopus citations

Abstract

AKXD-23 recombinant inbred mice develop myeloid tumors at a high frequency, unlike other AKXD recombinant inbred strains which develop B-cell lymphomas, T-cell lymphomas, or both. AKXD-23 myeloid tumors are monoclonal, and their DNA contains somatically acquired proviruses, suggesting that they are retrovirally induced. We identified a common site of ecotropic proviral integration that is present in the DNA of all AKXD-23 myeloid tumors that were analyzed and in the DNA of all myeloid tumors that occur in AKXD strains other than AKXD-23. We designated this locus Evi-1 (ecotropic viral integration site 1). Rearrangements in the Evi-1 locus were also detected in the DNA of a number of myeloid tumors and myeloid cell lines isolated from strains other than AKXD. In contrast, few Evi-1 rearrangements were detected in the DNA of T- or B-cell tumors. Evi-1 may thus identify a new proto-oncogene locus that is involved in myeloid disease.

Original languageEnglish (US)
Pages (from-to)301-308
Number of pages8
JournalMolecular and Cellular Biology
Volume8
Issue number1
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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