Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene

Iris Pecker; Karen B. Avraham; Debra J. Gilbert; Kinneret Savitsky; Galit Rotman; Reli Harnik; Toshiyuki Fukao; Evelin Schröck; Shinji Hirotsune; Danilo A. Tagle; Francis S. Collins; Anthony Wynshaw-Boris; Thomas Ried; Neal G. Copeland; Nancy A. Jenkins; Yosef Shiloh; Yael Ziv

doi:10.1006/geno.1996.0320

Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene

Iris Pecker, Karen B. Avraham, Debra J. Gilbert, Kinneret Savitsky, Galit Rotman, Reli Harnik, Toshiyuki Fukao, Evelin Schröck, Shinji Hirotsune, Danilo A. Tagle, Francis S. Collins, Anthony Wynshaw-Boris, Thomas Ried, Neal G. Copeland, Nancy A. Jenkins, Yosef Shiloh, Yael Ziv

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Abstract

Atm, the mouse homolog of the human ATM gene defective in ataxia- telangiectasia (A-T), has been identified. The entire coding sequence of the Atm transcript was cloned and found to contain an open reading frame encoding a protein of 3066 amino acids with 84% overall identity and 91% similarity to the human ATM protein. Variable levels of expression of Atm were observed in different tissues. Fluorescence in situ hybridization and linkage analysis located the Atm gene on mouse chromosome 9, band 9C, in a region homologous to the ATM region on human chromosome 11q22-q23.

Original language	English (US)
Pages (from-to)	39-45
Number of pages	7
Journal	Genomics
Volume	35
Issue number	1
DOIs	https://doi.org/10.1006/geno.1996.0320
State	Published - Jul 1 1996

ASJC Scopus subject areas

Genetics

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Pecker, I., Avraham, K. B., Gilbert, D. J., Savitsky, K., Rotman, G., Harnik, R., Fukao, T., Schröck, E., Hirotsune, S., Tagle, D. A., Collins, F. S., Wynshaw-Boris, A., Ried, T., Copeland, N. G., Jenkins, N. A., Shiloh, Y., & Ziv, Y. (1996). Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene. Genomics, 35(1), 39-45. https://doi.org/10.1006/geno.1996.0320

Pecker, I, Avraham, KB, Gilbert, DJ, Savitsky, K, Rotman, G, Harnik, R, Fukao, T, Schröck, E, Hirotsune, S, Tagle, DA, Collins, FS, Wynshaw-Boris, A, Ried, T, Copeland, NG , Jenkins, NA, Shiloh, Y & Ziv, Y 1996, 'Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene', Genomics, vol. 35, no. 1, pp. 39-45. https://doi.org/10.1006/geno.1996.0320

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title = "Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene",

abstract = "Atm, the mouse homolog of the human ATM gene defective in ataxia- telangiectasia (A-T), has been identified. The entire coding sequence of the Atm transcript was cloned and found to contain an open reading frame encoding a protein of 3066 amino acids with 84\% overall identity and 91\% similarity to the human ATM protein. Variable levels of expression of Atm were observed in different tissues. Fluorescence in situ hybridization and linkage analysis located the Atm gene on mouse chromosome 9, band 9C, in a region homologous to the ATM region on human chromosome 11q22-q23.",

author = "Iris Pecker and Avraham, \{Karen B.\} and Gilbert, \{Debra J.\} and Kinneret Savitsky and Galit Rotman and Reli Harnik and Toshiyuki Fukao and Evelin Schr{\"o}ck and Shinji Hirotsune and Tagle, \{Danilo A.\} and Collins, \{Francis S.\} and Anthony Wynshaw-Boris and Thomas Ried and Copeland, \{Neal G.\} and Jenkins, \{Nancy A.\} and Yosef Shiloh and Yael Ziv",

note = "Funding Information: We thank D. Swing, B. Cho, D. Barnhart, and D. Larson for excellent assistance, P. Soriano for providing us with the Csk probe, and Dr. Y. J. Hirschberg for helpful discussions. This study was supported by research grants from the A±T Children's Project, the A± T Medical Research Foundation, the Thomas Appeal (A±T Medical Research Trust), The United States±Israel Binational Science Foundation, the National Institute of Neurological Disorders Stroke (to Y.S.), The National Cancer Institute, DHHS, under Contract with ABL (N.G.C., N.A.J., and K.B.A.), and a grant from the National Institutes of Health, National Research Service Award 5F32GM15909-02 from the National Institute of General Medical Sciences (K.B.A.).",

year = "1996",

month = jul,

day = "1",

doi = "10.1006/geno.1996.0320",

language = "English (US)",

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T1 - Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene

AU - Pecker, Iris

AU - Avraham, Karen B.

AU - Gilbert, Debra J.

AU - Savitsky, Kinneret

AU - Rotman, Galit

AU - Harnik, Reli

AU - Fukao, Toshiyuki

AU - Schröck, Evelin

AU - Hirotsune, Shinji

AU - Tagle, Danilo A.

AU - Collins, Francis S.

AU - Wynshaw-Boris, Anthony

AU - Ried, Thomas

AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

AU - Shiloh, Yosef

AU - Ziv, Yael

N1 - Funding Information: We thank D. Swing, B. Cho, D. Barnhart, and D. Larson for excellent assistance, P. Soriano for providing us with the Csk probe, and Dr. Y. J. Hirschberg for helpful discussions. This study was supported by research grants from the A±T Children's Project, the A± T Medical Research Foundation, the Thomas Appeal (A±T Medical Research Trust), The United States±Israel Binational Science Foundation, the National Institute of Neurological Disorders Stroke (to Y.S.), The National Cancer Institute, DHHS, under Contract with ABL (N.G.C., N.A.J., and K.B.A.), and a grant from the National Institutes of Health, National Research Service Award 5F32GM15909-02 from the National Institute of General Medical Sciences (K.B.A.).

PY - 1996/7/1

Y1 - 1996/7/1

N2 - Atm, the mouse homolog of the human ATM gene defective in ataxia- telangiectasia (A-T), has been identified. The entire coding sequence of the Atm transcript was cloned and found to contain an open reading frame encoding a protein of 3066 amino acids with 84% overall identity and 91% similarity to the human ATM protein. Variable levels of expression of Atm were observed in different tissues. Fluorescence in situ hybridization and linkage analysis located the Atm gene on mouse chromosome 9, band 9C, in a region homologous to the ATM region on human chromosome 11q22-q23.

AB - Atm, the mouse homolog of the human ATM gene defective in ataxia- telangiectasia (A-T), has been identified. The entire coding sequence of the Atm transcript was cloned and found to contain an open reading frame encoding a protein of 3066 amino acids with 84% overall identity and 91% similarity to the human ATM protein. Variable levels of expression of Atm were observed in different tissues. Fluorescence in situ hybridization and linkage analysis located the Atm gene on mouse chromosome 9, band 9C, in a region homologous to the ATM region on human chromosome 11q22-q23.

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Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene

Abstract

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