ID proteins regulate diverse aspects of cancer progression and provide novel therapeutic opportunities

Radhika Nair, Wee Siang Teo, Vivek Mittal, Alexander Swarbrick

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

The inhibitor of differentiation (ID) proteins are helix-loop-helix transcriptional repressors with established roles in stem cell self-renewal, lineage commitment, and niche interactions. While deregulated expression of ID proteins in cancer was identified more than a decade ago, emerging evidence has revealed a central role for ID proteins in neoplastic progression of multiple tumor types that often mirrors their function in physiological stem and progenitor cells. ID proteins are required for the maintenance of cancer stem cells, self-renewal, and proliferation in a range of malignancies. Furthermore, ID proteins promote metastatic dissemination through their role in remodeling the tumor microenvironment and by promoting tumor-associated endothelial progenitor cell proliferation and mobilization. Here, we discuss the latest findings in this area and the clinical opportunities that they provide.

Original languageEnglish (US)
Pages (from-to)1407-1415
Number of pages9
JournalMolecular Therapy
Volume22
Issue number8
DOIs
StatePublished - Aug 2014

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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