TY - JOUR
T1 - ICU and Ventilator Mortality Among Critically Ill Adults With Coronavirus Disease 2019∗
AU - The Emory COVID-19 Quality and Clinical Research Collaborative
AU - Auld, Sara C.
AU - Caridi-Scheible, Mark
AU - Blum, James M.
AU - Robichaux, Chad
AU - Kraft, Colleen
AU - Jacob, Jesse T.
AU - Jabaley, Craig S.
AU - Carpenter, David
AU - Kaplow, Roberta
AU - Hernandez-Romieu, Alfonso C.
AU - Adelman, Max W.
AU - Martin, Greg S.
AU - Coopersmith, Craig M.
AU - Murphy, David J.
N1 - Publisher Copyright:
Copyright © 2020 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Objectives: To determine mortality rates among adults with critical illness from coronavirus disease 2019. Design: Observational cohort study of patients admitted from March 6, 2020, to April 17, 2020. Setting: Six coronavirus disease 2019 designated ICUs at three hospitals within an academic health center network in Atlanta, Georgia, United States. Patients: Adults greater than or equal to 18 years old with confirmed severe acute respiratory syndrome-CoV-2 disease who were admitted to an ICU during the study period. Interventions: None. Measurements and Main Results: Among 217 critically ill patients, mortality for those who required mechanical ventilation was 35.7% (59/165), with 4.8% of patients (8/165) still on the ventilator at the time of this report. Overall mortality to date in this critically ill cohort is 30.9% (67/217) and 60.4% (131/217) patients have survived to hospital discharge. Mortality was significantly associated with older age, lower body mass index, chronic renal disease, higher Sequential Organ Failure Assessment score, lower Pao2/Fio2 ratio, higher d-dimer, higher C-reactive protein, and receipt of mechanical ventilation, vasopressors, renal replacement therapy, or vasodilator therapy. Conclusions: Despite multiple reports of mortality rates exceeding 50% among critically ill adults with coronavirus disease 2019, particularly among those requiring mechanical ventilation, our early experience indicates that many patients survive their critical illness.
AB - Objectives: To determine mortality rates among adults with critical illness from coronavirus disease 2019. Design: Observational cohort study of patients admitted from March 6, 2020, to April 17, 2020. Setting: Six coronavirus disease 2019 designated ICUs at three hospitals within an academic health center network in Atlanta, Georgia, United States. Patients: Adults greater than or equal to 18 years old with confirmed severe acute respiratory syndrome-CoV-2 disease who were admitted to an ICU during the study period. Interventions: None. Measurements and Main Results: Among 217 critically ill patients, mortality for those who required mechanical ventilation was 35.7% (59/165), with 4.8% of patients (8/165) still on the ventilator at the time of this report. Overall mortality to date in this critically ill cohort is 30.9% (67/217) and 60.4% (131/217) patients have survived to hospital discharge. Mortality was significantly associated with older age, lower body mass index, chronic renal disease, higher Sequential Organ Failure Assessment score, lower Pao2/Fio2 ratio, higher d-dimer, higher C-reactive protein, and receipt of mechanical ventilation, vasopressors, renal replacement therapy, or vasodilator therapy. Conclusions: Despite multiple reports of mortality rates exceeding 50% among critically ill adults with coronavirus disease 2019, particularly among those requiring mechanical ventilation, our early experience indicates that many patients survive their critical illness.
KW - adult
KW - artificial
KW - coronavirus
KW - critical care
KW - intubation
KW - mortality
KW - respiration
KW - respiratory distress syndrome
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U2 - 10.1097/CCM.0000000000004457
DO - 10.1097/CCM.0000000000004457
M3 - Article
C2 - 32452888
AN - SCOPUS:85087925074
VL - 48
SP - E799-E804
JO - Critical Care Medicine
JF - Critical Care Medicine
SN - 0090-3493
IS - 9
ER -