I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations

Keyphrases

• COVID-19 100%
• Acute Respiratory Failure 100%
• Coronavirus Disease (COVID) 100%
• Adaptive Platform Trial 100%
• I-SPY 100%
• Investigational Agents 66%
• Severe COVID-19 33%
• Imaging Analysis 16%
• School of Medicine 16%
• Improved Outcomes 16%
• Molecular Analysis 16%
• Trial Registration 16%
• Adaptation 16%
• Ethics 16%
• Efficacy Trial 16%
• Recovery Time 16%
• Medical Journals 16%
• Academic Hospital 16%
• Bayesian Modeling 16%
• Therapeutic Response 16%
• Community Hospital 16%
• Serial Studies 16%
• Trial Design 16%
• Statistical Design 16%
• Concurrent Control 16%
• Trial Phase 16%
• Design Challenges 16%
• Forest School 16%
• Design Rationale 16%
• COVID-19 Pandemic 16%
• Platform Trials 16%
• Geographical Diversity 16%
• Adaptive Platform 16%
• Central Institutional Review Board 16%
• Trial Network 16%

Medicine and Dentistry

• Acute Respiratory Failure 100%
• COVID-19 100%
• Arm 40%
• Medicine 10%
• Treatment Response 10%
• Primary Outcome 10%
• Registration Number 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Pandemic 100%
• Acute Respiratory Failure 100%