Hypocellularity in myelodysplastic syndrome is an independent factor which predicts a favorable outcome

Gang Yue, Suyang Hao, Oluwole Fadare, Stephen Baker, Olga Pozdnyakova, Naomi Galili, Bruce A. Woda, Azra Raza, Sa A. Wang

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Hypocellular myelodysplastic syndrome (MDS) represents only a small portion of MDS, of which, the clinical significance has not been well-defined. By using currently accepted age-adjusted criteria to define hypocellularity as <30% in patients <70 years old, and <20% in >70 years old, we identified 163 (15.5%) hypocelluar MDS from 1049 consecutive adult MDS patients over an 11-year period (1995-2006). Compared to normal/hypercellular MDS, hypocellular MDS patients were younger (p < 0.01), less anemic (p = 0.02), but more neutropenic (p < 0.001) and thrombocytopenic (p = 0.05), and had a comparable cytogenetic risk group distribution (p = 0.09) and international prognostic scores (IPSS, p = 0.13). With a median follow-up of 52 months, hypocellular MDS showed a favorable overall survival (56 months versus 28 months, log-rank p < 0.0001) over normal/hypocellular MDS, and this survival preference was also demonstrated in all IPSS groups and cytogenetic risk groups, and was independent of all other risk factors (Cox regression test, p = 0.01). In conclusion, our study demonstrated that hypocellular MDS has characteristic clinicopathologic features, and bone marrow hypocellularity in MDS is an independent factor which predicts a favorable outcome.

Original languageEnglish (US)
Pages (from-to)553-558
Number of pages6
JournalLeukemia Research
Volume32
Issue number4
DOIs
StatePublished - Apr 2008

Keywords

  • Cytogenetics
  • Hypocellular
  • IPSS risk groups
  • Myelodysplastic syndrome
  • Survival

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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