@article{663f72254b3445339ab239b0172413a2,
title = "Hypervariable yellow (Ahvy), a new murine agouti mutation: Ahvy displays the largest variation in coat color phenotypes of all known agouti alleles",
abstract = "A new coat color mutation, which occurred spontaneously in the C3H/HeJ strain, has been identified. The original C3H/HeJ male mouse carrying the mutation was unusual because its coat color appeared mostly yellow, in contrast to the wild-type agouti coat normally exhibited by mice of the C3H/HeJ strain. Genetic crosses showed that the mutant phenotype was inherited as a single autosomal dominant gene. The mutation was backcrossed onto a C57BL/6J background and tested for allelism with the agouti locus. The results showed that the mutation, named hypervariable yellow (A(hvy)), is a new allele of the agouti locus. A(hvy) is unique because mice carrying the mutation can display a range of coat color from pure yellow to almost pure black. The A(hvy) mutation is responsible for the largest range of coat color phenotypes yet identified for any single agouti mutation.",
author = "Siracusa, {L. D.} and Washburn, {L. L.} and Swing, {D. A.} and Argeson, {A. C.} and Jenkins, {N. A.} and Copeland, {N. G.}",
note = "Funding Information: From the Department of Microbiology and Immunology, Jefferson Cancer Institute, 233 South 10th Street, Philadelphia, PA 19107 (Siracusa and Argeson), The Jackson Laboratory, Bar Harbor, Maine (Washburn), and the Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland (Swing, Jen-kins, and Copeland). We thank K. J. Moore for the photography; M. Dickinson, J. Dietz, F. Dorsey, and C. Goldstein for technical assistance; and P. Shaw and U. Schibler for the Psp probe. We thank A. M. Buchberg, K. R. Johnson, and P. W. Lane for reviewing the manuscript. This research was supported in part by the National Cancer Institute, DHHS, under contract no. N01-CO-74101 with ABL and by grants from the National Institutes of Health and the American Cancer Society by L.D.S. Maintenance of this stock at the Jackson Laboratory was supported by NIH grant no. PO1 RR01183 to The Mouse Mutant Resource at The Jackson Laboratory. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "1995",
month = mar,
doi = "10.1093/oxfordjournals.jhered.a111541",
language = "English (US)",
volume = "86",
pages = "121--128",
journal = "Journal of Heredity",
issn = "0022-1503",
publisher = "Oxford University Press",
number = "2",
}