Hypertension Management in Patients with Chronic Kidney Disease

Sean A. Hebert, Hassan N. Ibrahim

Research output: Contribution to journalReview articlepeer-review


Hypertension and chronic kidney disease are closely linked. Patients with chronic kidney disease have hypertension almost universally and uncontrolled hypertension accelerates the decline in kidney function. The pathophysiology of hypertension in chronic kidney disease is complex, but is largely related to reduced nephron mass, sympathetic nervous system overactivation, involvement of the renin-angiotensin-aldosterone system, and generalized endothelial dysfunction. Consensus guidelines for blood pressure targets have adopted a blood pressure <120/80 mm Hg in native chronic kidney disease and <130/80 mm Hg in kidney transplant recipients. Guidelines also strongly advocate for renin-angiotensin-aldosterone system blockade as the first-line therapy.

Original languageEnglish (US)
Pages (from-to)41-49
Number of pages9
JournalMethodist DeBakey cardiovascular journal
Issue number4
StatePublished - 2022


  • ambulatory blood pressure monitor
  • chronic kidney disease
  • hypertension
  • masked hypertension

ASJC Scopus subject areas

  • Medicine(all)


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