Hypertension and renal outcomes in normotensive kidney donors with multiple renal arteries

Nisarg V. Gandhi, Dina N. Murad, Duc T. Nguyen, Edward A. Graviss, Hassan N. Ibrahim

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Having multiple renal arteries (MRA) has been linked to hypertension development. Whether kidney donors who are left with MRA in the nondonated kidney incur a higher risk of hypertension has not been studied. We compared the development of hypertension, reduced estimated glomerular filtration rate (eGFR), cardiovascular disease, and mortality in 2624 normotensive kidney donors with MRA in the nondonated kidney and to 2624 propensity score matched normotensive donor controls with a single renal artery. In total, 35% of donors had MRA. Donors with MRA were less likely to have undergone a left nephrectomy (51% vs. 83%). Postdonation hypertension was associated with age, male gender, non-White ethnicity, obesity, and family history of hypertension. Having MRA was not associated with risk of hypertension; aHR 0.92 (95% CI 0.82-1.03), P = 0.16. After 17 ± 11 years from donation, a similar proportion of donors with and without MRA developed cardiovascular disease, proteinuria and eGFR <30, <45 and <60 mL/min/1.73 m 2 and the multivariable risks of developing these outcomes were similar in the two groups. Our study did not show increased risk for hypertension, reduced eGFR, proteinuria or cardiovascular disease in donors with MRA in the remaining kidney and without hypertension at donation.

Original languageEnglish (US)
Pages (from-to)2382-2393
Number of pages12
JournalTransplant International
Issue number11
StatePublished - Nov 2021


  • hypertension
  • kidney donors
  • kidney transplantation
  • multiple renal arteries
  • Glomerular Filtration Rate
  • Humans
  • Male
  • Living Donors
  • Hypertension/etiology
  • Kidney
  • Renal Artery
  • Kidney Transplantation/adverse effects
  • Nephrectomy
  • Retrospective Studies

ASJC Scopus subject areas

  • Transplantation


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