Hydroxyapatite prosthesis extrusion

Jeffrey T. Vrabec, Karen Stierman, James J. Grady

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Objective: To examine the mechanism of prosthesis extrusion and evaluate preoperative and postoperative variables associated with extrusion of hydroxyapatite prostheses for ossicular reconstruction. Study Design: Retrospective case review. Setting: Tertiary referral, university medical center Patients: Patients undergoing ossiculoplasty with a hydroxyapatite prosthesis and having at least six months follow-up. Main Outcome Measure: Prosthesis extrusion, defined as loss of the tympanic membrane resulting in exposure of the prosthesis. Extrusion is further classified into early (< 2 months) and late (> 6 months). Results: Early extrusion or tympanoplasty graft failure occurred in 15/195 cases (8%). Late extrusion was seen in 17/125 cases (14%). Cases exhibiting late extrusion had a significantly greater incidence of postoperative atelectasis (p < 0.0001), recurrent otitis media (p < 0.0001), and myringitis (p = 0.003) than those with retention of the prosthesis. Regression analysis found an abnormal contralateral ear increased the risk of post-operative recurrent otitis media, while staged surgery reduced the risk, odds ratios of 3.56 (95% confidence interval 2.20-9.37) and 6.84 (95% CI 4.24-17.76) respectively. There were no preoperative variables that predicted postoperative atelectasis or myringitis. Conclusions: Recurrent otitis media, myringitis, and atelectasis developing after ossiculoplasty are associated with a greater risk of prosthesis extrusion. Predicting postoperative complications from preoperative and intraoperative findings proved difficult. Measures to prevent atelectasis, such as covering the prosthesis with cartilage, are recommended at the time of ossiculoplasty.

Original languageEnglish (US)
Pages (from-to)653-656
Number of pages4
JournalOtology and Neurotology
Issue number5
StatePublished - Sep 2002


  • Atelectasis
  • Conductive hearing loss
  • Hydroxyapatite
  • Ossiculoplasty
  • Tympanoplasty

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Sensory Systems
  • Clinical Neurology


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