Human large granular lymphocytes induce immunoglobulin synthesis after bone marrow transplantation

Malcolm K. Brenner, Anna Vyakarnam, Joyce E. Reittie, Jennifer Z. Wimperis, Jean Philippe Grob, A. Victor Hoffbrand, H. Grant Prentice

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Following T cell-depleted bone marrow transplantation, helper T cell numbers remain depressed for some months. Nonetheless, functional B cells can be adoptively transferred to the recipients of such grafts, where they continue to secrete antibody. We now show that immunoglobulin production by these transferred B cells is induced by activated large granular lymphocytes (LGL) which circulate in the recipients in substantial numbers during the immediate post-transplant period. The LGL are CD3 negative and therefore provide help in an antigen-unlinked manner. Helper effects for autologous (donor) B cells are augmented by the addition of anti-LFA-2 (anti-CD2) which appears to act by blocking recruitment of LGL inhibitory to developing B cells. In contrast antibody to the β chain of LFA-1, which effectively reduces natural killer activity of LGL, does not influence their helper function. The peripheral blood LGL fraction thus contains both helper and cytotoxic activity, which can be distinguished by appropriate monoclonal antibodies.

Original languageEnglish (US)
Pages (from-to)43-47
Number of pages5
JournalEuropean Journal of Immunology
Volume17
Issue number1
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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