Human cytomegalovirus is not implicated in benign prostatic hyperplasia: A study using immunohistochemistry and the polymerase chain reaction

A. M.F. Stapleton, R. H. Williams, T. L. Timme, G. Yang, Luan Truong, T. C. Thompson

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Purpose: To evaluate whether human cytomegalovirus (CMV) may play a role in the pathogenesis of benign prostatic hyperplasia. Materials and Methods: We used immunohistochemistry and the polymerase chain reaction (PCR) to evaluate the presence of CMV in normal prostatic tissue (n=12) and BPH tissue (n=21). Results: Immunostaining for CMV in prostatic tissue was negative; however, staining was evident in mononuclear cells seen in the tissues of both groups. With nested PCR, CMV genomic material was demonstrated in 1 tissue specimen from each group (p >0.1). Conclusions: These data suggest that CMV is unlikely to be a significant factor in the pathogenesis of BPH.

Original languageEnglish (US)
Pages (from-to)542-545
Number of pages4
JournalJournal of Urology
Volume156
Issue number2
DOIs
StatePublished - Aug 1996

Keywords

  • Cytomegalovirus
  • Immunohistochemistry
  • Polymerase chain reaction
  • Prostatic hyperplasia

ASJC Scopus subject areas

  • Urology

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