Abstract
Elevated levels of C-reactive protein (CRP) are present in many disease situations including malignancies and may contribute to the pathogenesis of cardiovascular disorders. This study was undertaken in a myeloma setting to determine whether CRP affects tumor cell growth and survival. We show that CRP enhanced myeloma cell proliferation under stressed conditions and protected myeloma cells from chemotherapy drug-induced apoptosis in vitro and in vivo. CRP binds activating Fcγ receptors; activates PI3K/Akt, ERK, and NF-κB pathways; and inhibits caspase cascade activation induced by chemotherapy drugs. CRP also enhanced myeloma cell secretion of IL-6 and synergized with IL-6 to protect myeloma cells from chemotherapy drug-induced apoptosis. Thus, our results implicate CRP as a potential target for cancer treatment.
Original language | English (US) |
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Pages (from-to) | 252-265 |
Number of pages | 14 |
Journal | Cancer Cell |
Volume | 12 |
Issue number | 3 |
DOIs | |
State | Published - Sep 11 2007 |
Keywords
- CELLCYCLE
ASJC Scopus subject areas
- Oncology
- Cell Biology
- Cancer Research